{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:48:26Z","timestamp":1792039706182,"version":"4.4.0"},"reference-count":58,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,8,26]],"date-time":"2013-08-26T00:00:00Z","timestamp":1377475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31171837"],"award-info":[{"award-number":["31171837"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["30970225"],"award-info":[{"award-number":["30970225"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Genetically Modified Organisms Breeding Major Projects of China","award":["2009ZX08009-092B"],"award-info":[{"award-number":["2009ZX08009-092B"]}]}],"content-domain":{"domain":["bsppjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Plant Pathology"],"published-print":{"date-parts":[[2014,1]]},"abstract":"Summary<\/jats:title>\n \n Mitogen\u2010activated protein kinase (\n MAPK<\/jats:styled-content>\n ) cascades are involved in plant development, stress responses and hormonal signal transduction.\n MAPK<\/jats:styled-content>\n kinases (\n MAPKKs<\/jats:styled-content>\n ), as the key nodes in these cascades, link\n MAPKs<\/jats:styled-content>\n and\n MAPKK<\/jats:styled-content>\n kinases (\n MAPKKKs<\/jats:styled-content>\n ). In this study,\n \n G<\/jats:styled-content>\n h\n MKK<\/jats:styled-content>\n 4\n <\/jats:italic>\n , a novel group\n C MAPKK<\/jats:styled-content>\n gene from cotton (\n \n G<\/jats:styled-content>\n ossypium hirsutum\n <\/jats:italic>\n ), was isolated and identified. Its expression can be induced by various stresses and signalling molecules. The overexpression of\n \n GhMKK4<\/jats:styled-content>\n <\/jats:italic>\n in\n \n N<\/jats:styled-content>\n icotiana benthamiana\n <\/jats:italic>\n enhanced its susceptibility to bacterial and fungal pathogens, but had no significant effects on salt or drought tolerance. Notably, the overexpressing plants showed increased sensitivity to abscisic acid (\n ABA<\/jats:styled-content>\n ) and gibberellin\n A<\/jats:styled-content>\n 3 (\n GA<\/jats:styled-content>\n 3), and\n ABA<\/jats:styled-content>\n and gibberellin (\n GA<\/jats:styled-content>\n ) signalling were affected on infection with\n \n R<\/jats:styled-content>\n alstonia solanacearum\n <\/jats:italic>\n bacteria. Furthermore, the overexpressing plants showed more reactive oxygen species (\n ROS<\/jats:styled-content>\n ) accumulation and stronger inhibition of catalase (\n CAT<\/jats:styled-content>\n ), a\n ROS<\/jats:styled-content>\n \u2010scavenging enzyme, than control plants after salicylic acid (\n SA<\/jats:styled-content>\n ) treatment. Interestingly, two genes encoding ornithine decarboxylase (\n ODC<\/jats:styled-content>\n ) and\n \n S<\/jats:styled-content>\n <\/jats:italic>\n \u2010adenosylmethionine decarboxylase (\n SAMDC<\/jats:styled-content>\n ), the key enzymes in polyamine synthesis, exhibited reduced\n \n R<\/jats:styled-content>\n .\u2009solanacearum\n <\/jats:italic>\n \u2010induced expression in overexpressing plants. These findings broaden our knowledge about the functions of\n MAPKKs<\/jats:styled-content>\n in diverse signalling pathways and the negative regulation of disease resistance in the cotton crop.\n <\/jats:p>","DOI":"10.1111\/mpp.12067","type":"journal-article","created":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T03:51:27Z","timestamp":1375329087000},"page":"94-108","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Overexpression of cotton\n \n GhMKK4<\/scp>\n <\/i>\n enhances disease susceptibility and affects abscisic acid, gibberellin and hydrogen peroxide signalling in transgenic\n \n N<\/scp>\n icotiana benthamiana\n <\/i>"],"prefix":"10.1111","volume":"15","author":[{"given":"Yuzhen","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Crop Biology Shandong Key Laboratory of Crop Biology Shandong Agricultural University Taian Shandong 271018 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Crop Biology Shandong Key Laboratory of Crop Biology Shandong Agricultural University Taian Shandong 271018 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Lu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Crop Biology Shandong Key Laboratory of Crop Biology Shandong Agricultural University Taian Shandong 271018 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuling","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Crop Biology Shandong Key Laboratory of Crop Biology Shandong Agricultural University Taian Shandong 271018 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang\u2010Ai","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Crop Biology Shandong Key Laboratory of Crop Biology Shandong Agricultural University Taian Shandong 271018 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingqi","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Crop Biology Shandong Key Laboratory of Crop Biology Shandong Agricultural University Taian Shandong 271018 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.106.048041"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plantsci.2005.05.004"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.104.025833"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tplants.2009.12.001"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/415977a"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1364-3703.2007.00437.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.010605"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI-20-5-0589"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.010256"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11104-009-0161-4"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.105.037846"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.106.050039"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tplants.2012.05.009"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.109.137943"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10725-008-9333-0"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2008.300"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tplants.2006.02.007"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jplph.2007.03.010"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/jxb\/err162"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.106.048058"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/pcp\/pcp009"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2008.03646.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-5266(02)00285-6"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI-20-4-0335"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.07.064"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2010.04264.x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.112.097253"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3040.2011.02329.x"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M401099200"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2008.29"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbi.2007.08.008"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1360-1385(02)02302-6"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2006.02888.x"},{"key":"e_1_2_6_35_1","first-page":"165","article-title":"Osmotic stress induces rapid activation of a salicylic acid\u2010induced protein kinase and a homolog of protein kinase ASK1 in tobacco cells","volume":"12","author":"Mikolajczyk M.","year":"2000","journal-title":"Plant Cell"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1071\/FP02231"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.115.1.137"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0711301105"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-arplant-042809-112252"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9452(02)00272-8"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2199-12-22"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-5266(03)00092-X"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.106.046581"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2006.03022.x"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2004.06.023"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2004.02028.x"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9452(03)00030-X"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-8137.2003.00802.x"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.106.048298"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/pcp\/pcq037"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.108.127605"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M801392200"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.127.1.315"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11103-007-9267-3"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06543"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2229-12-144"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2011.08056.x"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/jxb\/ers086"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2007.03294.x"}],"container-title":["Molecular Plant Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fmpp.12067","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fmpp.12067","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/mpp.12067","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/mpp.12067","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bsppjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/mpp.12067","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T16:37:08Z","timestamp":1762274228000},"score":1,"resource":{"primary":{"URL":"https:\/\/bsppjournals.onlinelibrary.wiley.com\/doi\/10.1111\/mpp.12067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,26]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1111\/mpp.12067"],"URL":"https:\/\/doi.org\/10.1111\/mpp.12067","archive":["Portico"],"relation":{},"ISSN":["1464-6722","1364-3703"],"issn-type":[{"value":"1464-6722","type":"print"},{"value":"1364-3703","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,26]]},"assertion":[{"value":"2013-08-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}