{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:52:15Z","timestamp":1791568335422,"version":"4.3.4"},"reference-count":56,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,8,24]],"date-time":"2014-08-24T00:00:00Z","timestamp":1408838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bsppjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Plant Pathology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Non\u2010self\u2010recognition of microorganisms partly relies on the perception of microbe\u2010associated molecular patterns (\n                    <jats:styled-content style=\"fixed-case\">MAMPs<\/jats:styled-content>\n                    ) and leads to the activation of an innate immune response.\n                    <jats:italic>Bacillus subtilis<\/jats:italic>\n                    produces three main families of cyclic lipopeptides (\n                    <jats:styled-content style=\"fixed-case\">LPs<\/jats:styled-content>\n                    ), namely surfactins, iturins and fengycins. Although\n                    <jats:styled-content style=\"fixed-case\">LPs<\/jats:styled-content>\n                    are involved in induced systemic resistance (\n                    <jats:styled-content style=\"fixed-case\">ISR<\/jats:styled-content>\n                    ) activation, little is known about defence responses induced by these molecules and their involvement in local resistance to fungi. Here, we showed that purified surfactin, mycosubtilin (iturin family) and plipastatin (fengycin family) are perceived by grapevine plant cells. Although surfactin and mycosubtilin stimulated grapevine innate immune responses, they differentially activated early signalling pathways and defence gene expression. By contrast, plipastatin perception by grapevine cells only resulted in early signalling activation. Gene expression analysis suggested that mycosubtilin activated salicylic acid (\n                    <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content>\n                    ) and jasmonic acid (\n                    <jats:styled-content style=\"fixed-case\">JA<\/jats:styled-content>\n                    ) signalling pathways, whereas surfactin mainly induced an\n                    <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content>\n                    \u2010regulated response. Although mycosubtilin and plipastatin displayed direct antifungal activity, only surfactin and mycosubtilin treatments resulted in a local long\u2010lasting enhanced tolerance to the necrotrophic fungus\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\n                      otrytis cinerea\n                    <\/jats:italic>\n                    in grapevine leaves. Moreover, challenge with specific strains overproducing surfactin and mycosubtilin led to a slightly enhanced stimulation of the defence response compared with the\n                    <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content>\n                    \u2010non\u2010producing strain of\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\n                      .\u2009subtilis\n                    <\/jats:italic>\n                    . Altogether, our results provide the first comprehensive view of the involvement of\n                    <jats:styled-content style=\"fixed-case\">LPs<\/jats:styled-content>\n                    from\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\n                      .\u2009subtilis\n                    <\/jats:italic>\n                    in grapevine plant defence and local resistance against the necrotrophic pathogen\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\n                      o.\u2009cinerea\n                    <\/jats:italic>\n                    . Moreover, this work is the first to highlight the ability of mycosubtilin to trigger an immune response in plants.\n                  <\/jats:p>","DOI":"10.1111\/mpp.12170","type":"journal-article","created":{"date-parts":[[2014,7,8]],"date-time":"2014-07-08T06:15:08Z","timestamp":1404800108000},"page":"177-187","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":172,"title":["Cyclic lipopeptides from\n                    <i>\n                      <scp>B<\/scp>\n                      acillus subtilis\n                    <\/i>\n                    activate distinct patterns of defence responses in grapevine"],"prefix":"10.1111","volume":"16","author":[{"given":"Giovanni","family":"Farace","sequence":"first","affiliation":[{"name":"URVVC\u2010EA 4707 Stress D\u00e9fenses et Reproductions des Plantes Universit\u00e9 de Reims Champagne\u2010Ardenne  BP 1039 F\u201051687 Reims cedex 2 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