{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:59:36Z","timestamp":1791251976421,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,12,15]],"date-time":"2014-12-15T00:00:00Z","timestamp":1418601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB924"],"award-info":[{"award-number":["SFB924"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bsppjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Plant Pathology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"Summary<\/jats:title>\n \n Folates are essential for one\u2010carbon transfer reactions in all organisms and contribute, for example, to\n de\u2009novo<\/jats:italic>\n \u2005\n DNA<\/jats:styled-content>\n synthesis. Here, we detected the folate precursors 7,8\u2010dihydropteroate (\n DHP<\/jats:styled-content>\n ) and 4\u2010amino\u20104\u2010deoxychorismate (\n ADC<\/jats:styled-content>\n ) in extracts from\n \n A<\/jats:styled-content>\n rabidopsis thaliana\n <\/jats:italic>\n plants by\n F<\/jats:styled-content>\n ourier transform ion cyclotron resonance\u2010mass spectrometry. The accumulation of\n DHP<\/jats:styled-content>\n , but not\n ADC<\/jats:styled-content>\n , was induced after infection of plants with\n \n P<\/jats:styled-content>\n seudomonas syringae\n <\/jats:italic>\n delivering the effector protein\n AvrRpm1<\/jats:styled-content>\n . Application of folic acid or the\n DHP<\/jats:styled-content>\n precursor 7,8\u2010dihydroneopterin (\n DHN<\/jats:styled-content>\n ) enhanced resistance in Arabidopsis to\n \n P<\/jats:styled-content>\n .\u2009syringae\n <\/jats:italic>\n and elevated the transcript accumulation of the salicylic acid (\n SA<\/jats:styled-content>\n ) marker gene\n \n PATHOGENESIS<\/jats:styled-content>\n \u2010\n RELATED1<\/jats:styled-content>\n <\/jats:italic>\n in both the treated and systemic untreated leaves.\n DHN<\/jats:styled-content>\n \u2010 and folic acid\u2010induced systemic resistance was dependent on\n SA<\/jats:styled-content>\n biosynthesis and signalling. Similar to\n SA<\/jats:styled-content>\n , folic acid application locally enhanced\n A<\/jats:styled-content>\n rabidopsis susceptibility to the necrotrophic fungus\n \n A<\/jats:styled-content>\n lternaria brassicicola\n <\/jats:italic>\n . Together, the data associate the folic acid pathway with innate immunity in\n A<\/jats:styled-content>\n rabidopsis, simultaneously activating local and systemic\n SA<\/jats:styled-content>\n \u2010dependent resistance to\n \n P<\/jats:styled-content>\n .\u2009syringae\n <\/jats:italic>\n and suppressing local resistance to\n \n A<\/jats:styled-content>\n .\u2009brassicicola\n <\/jats:italic>\n .\n <\/jats:p>","DOI":"10.1111\/mpp.12216","type":"journal-article","created":{"date-parts":[[2014,10,27]],"date-time":"2014-10-27T21:15:49Z","timestamp":1414444549000},"page":"616-622","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Folic acid induces salicylic acid\u2010dependent immunity in\n A<\/scp>\n rabidopsis and enhances susceptibility to\n \n A<\/scp>\n lternaria brassicicola\n <\/i>"],"prefix":"10.1111","volume":"16","author":[{"given":"Finni","family":"Wittek","sequence":"first","affiliation":[{"name":"Department of Environmental Sciences Institute of Biochemical Plant Pathology Helmholtz Zentrum Muenchen Ingolstaedter Landstr. 1 85764 Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basem","family":"Kanawati","sequence":"additional","affiliation":[{"name":"Department of Environmental Sciences Research Unit Analytical Biogeochemistry Helmholtz Zentrum Muenchen Ingolstaedter Landstr. 1 85764 Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Wenig","sequence":"additional","affiliation":[{"name":"Department of Environmental Sciences Institute of Biochemical Plant Pathology Helmholtz Zentrum Muenchen Ingolstaedter Landstr. 1 85764 Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Biotechnology of Natural Products Technische Universitaet Muenchen Liesel\u2010Beckmann\u2010Str. 1 85354 Freising Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Franz\u2010Oberdorf","sequence":"additional","affiliation":[{"name":"Biotechnology of Natural Products Technische Universitaet Muenchen Liesel\u2010Beckmann\u2010Str. 1 85354 Freising Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilfried","family":"Schwab","sequence":"additional","affiliation":[{"name":"Biotechnology of Natural Products Technische Universitaet Muenchen Liesel\u2010Beckmann\u2010Str. 1 85354 Freising Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Schmitt\u2010Kopplin","sequence":"additional","affiliation":[{"name":"Department of Environmental Sciences Research Unit Analytical Biogeochemistry Helmholtz Zentrum Muenchen Ingolstaedter Landstr. 1 85764 Neuherberg Germany"},{"name":"Analytical Food Chemistry Technische Universitaet Muenchen Alte Akademie 10 85354 Freising Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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