{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T17:49:04Z","timestamp":1762278544373,"version":"build-2065373602"},"reference-count":73,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T00:00:00Z","timestamp":1446768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Vietnam Overseas Scholarship Program"},{"name":"Daniel F. Millikan Graduate Endowment, Division of Plant Sciences"}],"content-domain":{"domain":["bsppjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Plant Pathology"],"published-print":{"date-parts":[[2016,5]]},"abstract":"Summary<\/jats:title>\n \n Plants have developed diverse mechanisms to fine tune defence responses to different types of enemy. Cross\u2010regulation between signalling pathways may allow the prioritization of one response over another. Previously, we identified\n \n SUPPRESSOR OF rps4\u2010RLD<\/jats:italic>\n <\/jats:styled-content>\n 1<\/jats:italic>\n (\n \n SRFR<\/jats:italic>\n <\/jats:styled-content>\n 1<\/jats:italic>\n ) as a negative regulator of\n \n ENHANCED DISEASE SUSCEPTIBILITY1<\/jats:italic>\n <\/jats:styled-content>\n (\n \n EDS1<\/jats:italic>\n <\/jats:styled-content>\n )\u2010dependent effector\u2010triggered immunity against the bacterial pathogen\n \n P<\/jats:italic>\n <\/jats:styled-content>\n seudomonas syringae<\/jats:italic>\n pv. tomato strain\n DC<\/jats:styled-content>\n 3000 expressing\n avr<\/jats:italic>\n \n R<\/jats:italic>\n <\/jats:styled-content>\n ps4<\/jats:italic>\n . The use of multiple stresses is a powerful tool to further define gene function. Here, we examined whether\n \n SRFR<\/jats:italic>\n <\/jats:styled-content>\n 1<\/jats:italic>\n also impacts resistance to a herbivorous insect in leaves and to a cyst nematode in roots. Interestingly,\n srfr1\u20101<\/jats:italic>\n plants showed increased resistance to herbivory by the beet army worm\n \n S<\/jats:italic>\n <\/jats:styled-content>\n podoptera exigua<\/jats:italic>\n and to parasitism by the cyst nematode\n \n H<\/jats:italic>\n <\/jats:styled-content>\n eterodera schachtii<\/jats:italic>\n compared with the corresponding wild\u2010type Arabidopsis accession\n RLD<\/jats:styled-content>\n . Using quantitative real\u2010time\n PCR<\/jats:styled-content>\n (\n qRT\u2010PCR<\/jats:styled-content>\n ) to measure the transcript levels of salicylic acid (\n SA<\/jats:styled-content>\n ) and jasmonate\/ethylene (\n JA<\/jats:styled-content>\n \/\n ET<\/jats:styled-content>\n ) pathway genes, we found that enhanced resistance of\n srfr1\u20101<\/jats:italic>\n plants to\n \n S<\/jats:italic>\n <\/jats:styled-content>\n .\u2009\n exigua<\/jats:italic>\n correlated with specific upregulation of the\n MYC<\/jats:styled-content>\n 2 branch of the\n JA<\/jats:styled-content>\n pathway concurrent with suppression of the\n SA<\/jats:styled-content>\n pathway. In contrast, the greater susceptibility of\n RLD<\/jats:styled-content>\n was accompanied by simultaneously increased transcript levels of\n SA<\/jats:styled-content>\n ,\n JA<\/jats:styled-content>\n and\n JA<\/jats:styled-content>\n \/\n ET<\/jats:styled-content>\n signalling pathway genes. Surprisingly, mutation of either\n \n SRFR<\/jats:italic>\n <\/jats:styled-content>\n 1<\/jats:italic>\n or\n \n EDS<\/jats:italic>\n <\/jats:styled-content>\n 1<\/jats:italic>\n increased resistance to\n \n H<\/jats:italic>\n <\/jats:styled-content>\n .\u2009schachtii<\/jats:italic>\n , indicating that the concurrent presence of both wild\u2010type genes promotes susceptibility. This finding suggests a novel form of resistance in Arabidopsis to the biotrophic pathogen\n \n H<\/jats:italic>\n <\/jats:styled-content>\n .\u2009schachtii<\/jats:italic>\n or a root\u2010specific regulation of the\n SA<\/jats:styled-content>\n pathway by\n EDS<\/jats:styled-content>\n 1, and places\n \n SRFR<\/jats:italic>\n <\/jats:styled-content>\n 1<\/jats:italic>\n at an intersection between multiple defence pathways.\n <\/jats:p>","DOI":"10.1111\/mpp.12304","type":"journal-article","created":{"date-parts":[[2015,8,27]],"date-time":"2015-08-27T06:16:43Z","timestamp":1440656203000},"page":"588-600","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The\n A<\/scp>\n rabidopsis immune regulator\n \n SRFR<\/i>\n <\/scp>\n 1<\/i>\n dampens defences against herbivory by\n \n S<\/i>\n <\/scp>\n podoptera exigua<\/i>\n and parasitism by\n \n H<\/i>\n <\/scp>\n eterodera schachtii<\/i>"],"prefix":"10.1111","volume":"17","author":[{"given":"Phuong Dung T.","family":"Nguyen","sequence":"first","affiliation":[{"name":"Division of Plant Sciences and Interdisciplinary Plant Group University of Missouri Columbia MO 65211\u20107310 USA"},{"name":"Christopher S. Bond Life Sciences Center University of Missouri Columbia MO 65211\u20107310 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Pike","sequence":"additional","affiliation":[{"name":"Division of Plant Sciences and Interdisciplinary Plant Group University of Missouri Columbia MO 65211\u20107310 USA"},{"name":"Christopher S. Bond Life Sciences Center University of Missouri Columbia MO 65211\u20107310 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianying","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Plant Sciences and Interdisciplinary Plant Group University of Missouri Columbia MO 65211\u20107310 USA"},{"name":"Christopher S. Bond Life Sciences Center University of Missouri Columbia MO 65211\u20107310 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arati","family":"Nepal Poudel","sequence":"additional","affiliation":[{"name":"Division of Plant Sciences and Interdisciplinary Plant Group University of Missouri Columbia MO 65211\u20107310 USA"},{"name":"Division of Biochemistry and Interdisciplinary Plant Group University of Missouri Columbia MO 65211\u20107310 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Heinz","sequence":"additional","affiliation":[{"name":"Division of Plant Sciences and Interdisciplinary Plant Group University of Missouri Columbia MO 65211\u20107310 USA"},{"name":"Christopher S. Bond Life Sciences Center University of Missouri Columbia MO 65211\u20107310 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack C.","family":"Schultz","sequence":"additional","affiliation":[{"name":"Division of Plant Sciences and Interdisciplinary Plant Group University of Missouri Columbia MO 65211\u20107310 USA"},{"name":"Christopher S. Bond Life Sciences Center University of Missouri Columbia MO 65211\u20107310 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abraham J.","family":"Koo","sequence":"additional","affiliation":[{"name":"Division of Biochemistry and Interdisciplinary Plant Group University of Missouri Columbia MO 65211\u20107310 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa G.","family":"Mitchum","sequence":"additional","affiliation":[{"name":"Division of Plant Sciences and Interdisciplinary Plant Group University of Missouri Columbia MO 65211\u20107310 USA"},{"name":"Christopher S. Bond Life Sciences Center University of Missouri Columbia MO 65211\u20107310 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidi M.","family":"Appel","sequence":"additional","affiliation":[{"name":"Division of Plant Sciences and Interdisciplinary Plant Group University of Missouri Columbia MO 65211\u20107310 USA"},{"name":"Christopher S. Bond Life Sciences Center University of Missouri Columbia MO 65211\u20107310 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Gassmann","sequence":"additional","affiliation":[{"name":"Division of Plant Sciences and Interdisciplinary Plant Group University of Missouri Columbia MO 65211\u20107310 USA"},{"name":"Christopher S. Bond Life Sciences Center University of Missouri Columbia MO 65211\u20107310 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,11,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.105.039982"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0031-9317.2001.1140112.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1211592"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2013.00364"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI-21-9-1205"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2009.03984.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tplants.2011.01.006"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.107.115691"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1228746"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10886-005-6070-y"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.105.063743"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.112.200303"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.109.139550"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-015-9018-1_1"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.19.5400"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI-01-12-0024-IA"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-313X.1999.00600.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.phyto.43.040204.135923"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-4811-8-45"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1364-3703.2010.00675.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1211641"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI-05-12-0106-FI"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI-9-0055"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI-20-3-0293"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbi.2013.07.001"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.4161\/psb.4.2.7682"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.109.139238"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001172"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/tpj.12527"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2009.03924.x"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-5266(02)00275-3"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2008.03669.x"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001111"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11651"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.105.066837"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8137.2010.03558.x"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.104.053389"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/nph.12323"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1203659"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.105.072348"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.111.177576"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2009.03949.x"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0055954"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.111.132332"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-092910-154055"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.21-4-459"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-0998.2010.02929.x"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2014.00407"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI-05-12-0118-FI"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1461-0248.2007.01093.x"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8137.2011.03675.x"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.04.024"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.21.11655"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0060230"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.113.115139"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/pcp\/pcn011"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.1991.00245.x"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004578"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1570-7458.1987.tb02204.x"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.2.549"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.113.120394"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1105664108"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11101-008-9117-1"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000772"},{"key":"e_1_2_6_66_1","first-page":"e0107","article-title":"Arabidopsis\u2013insect interactions","volume":"5","author":"Van Poecke R.M.","year":"2007","journal-title":"Arabidopsis Book"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2011.00047"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1093\/aob\/mct067"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2014.08.004"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1247357"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genet-102209-163500"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI-21-4-0424"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.114.243360"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/nplants.2015.49"}],"container-title":["Molecular Plant Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fmpp.12304","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fmpp.12304","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bsppjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/mpp.12304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T17:44:40Z","timestamp":1762278280000},"score":1,"resource":{"primary":{"URL":"https:\/\/bsppjournals.onlinelibrary.wiley.com\/doi\/10.1111\/mpp.12304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,6]]},"references-count":73,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1111\/mpp.12304"],"URL":"https:\/\/doi.org\/10.1111\/mpp.12304","archive":["Portico"],"relation":{},"ISSN":["1464-6722","1364-3703"],"issn-type":[{"type":"print","value":"1464-6722"},{"type":"electronic","value":"1364-3703"}],"subject":[],"published":{"date-parts":[[2015,11,6]]},"assertion":[{"value":"2015-11-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}