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The pathogen is known to produce a range of virulence factors, including phytotoxic zeamines and extracellular enzymes, but the mechanisms of virulence regulation remain vague. In this study, we identified a SlyA\/MarR family transcription factor SlyA in\n                    <jats:italic>D.\u00a0zeae<\/jats:italic>\n                    strain EC1. Disruption of\n                    <jats:italic>slyA<\/jats:italic>\n                    significantly decreased zeamine production, enhanced swimming and swarming motility, reduced biofilm formation and significantly decreased pathogenicity on rice. Quantitative polymerase chain reaction (qPCR) analysis confirmed the role of SlyA in transcriptional modulation of a range of genes associated with bacterial virulence.\n                    <jats:italic>In\u00a0trans<\/jats:italic>\n                    expression of\n                    <jats:italic>slyA<\/jats:italic>\n                    in\n                    <jats:italic>expI<\/jats:italic>\n                    mutants recovered the phenotypes of motility and biofilm formation, suggesting that SlyA is downstream of the acylhomoserine lactone\u2010mediated quorum sensing pathway. Taken together, the findings from this study unveil a key transcriptional regulatory factor involved in the modulation of virulence factor production and overall pathogenicity of\n                    <jats:italic>D.\u00a0zeae<\/jats:italic>\n                    EC1.\n                  <\/jats:p>","DOI":"10.1111\/mpp.12376","type":"journal-article","created":{"date-parts":[[2016,1,27]],"date-time":"2016-01-27T10:54:37Z","timestamp":1453892077000},"page":"1398-1408","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["SlyA regulates phytotoxin production and virulence in\n                    <i>Dickeya zeae<\/i>\n                    EC1"],"prefix":"10.1111","volume":"17","author":[{"given":"Jia\u2010Nuan","family":"Zhou","sequence":"first","affiliation":[{"name":"Guangdong Province Key Laboratory of Microbial Signals and Disease Control, Department of Plant Pathology South China Agricultural University Guangzhou 510642 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai\u2010Bao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Cell Biology  61 Biopolis Drive Singapore 138673"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Fa","family":"Lv","sequence":"additional","affiliation":[{"name":"Guangdong Province Key Laboratory of Microbial Signals and Disease Control, Department of Plant Pathology South China Agricultural University Guangzhou 510642 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Fan","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangdong Province Key Laboratory of Microbial Signals and Disease Control, Department of Plant Pathology South China Agricultural University Guangzhou 510642 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Sheng","family":"Liao","sequence":"additional","affiliation":[{"name":"Guangdong 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