{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:47:43Z","timestamp":1790844463700,"version":"4.1.0"},"reference-count":81,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,12,27]],"date-time":"2016-12-27T00:00:00Z","timestamp":1482796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31571973"],"award-info":[{"award-number":["31571973"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bsppjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Plant Pathology"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    The subversion of plant cellular functions is essential for bacterial pathogens to proliferate in host plants and cause disease. Most bacterial plant pathogens employ a type III secretion system to inject type III effector (T3E) proteins inside plant cells, where they contribute to the pathogen\u2010induced alteration of plant physiology. In this work, we found that the\n                    <jats:italic>Ralstonia solanacearum<\/jats:italic>\n                    T3E RipAY suppresses plant immune responses triggered by bacterial elicitors and by the phytohormone salicylic acid. Further biochemical analysis indicated that RipAY associates\n                    <jats:italic>in\u00a0planta<\/jats:italic>\n                    with thioredoxins from\n                    <jats:italic>Nicotiana benthamiana<\/jats:italic>\n                    and Arabidopsis. Interestingly, RipAY displays \u03b3\u2010glutamyl cyclotransferase (GGCT) activity to degrade glutathione in plant cells, which is required for the reported suppression of immune responses. Given the importance of thioredoxins and glutathione as major redox regulators in eukaryotic cells, RipAY activity may constitute a novel and powerful virulence strategy employed by\n                    <jats:italic>R.\u00a0solanacearum<\/jats:italic>\n                    to suppress immune responses and potentially alter general redox signalling in host cells.\n                  <\/jats:p>","DOI":"10.1111\/mpp.12504","type":"journal-article","created":{"date-parts":[[2016,10,21]],"date-time":"2016-10-21T14:09:17Z","timestamp":1477058957000},"page":"129-142","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":87,"title":["The\n                    <i>Ralstonia solanacearum<\/i>\n                    type III effector RipAY targets plant redox regulators to suppress immune responses"],"prefix":"10.1111","volume":"19","author":[{"given":"Yuying","family":"Sang","sequence":"first","affiliation":[{"name":"Shanghai Center for Plant Stress Biology, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences Shanghai 201602 China"},{"name":"CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences Shanghai 200031 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaru","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Center for Plant Stress Biology, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences Shanghai 201602 China"},{"name":"CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences Shanghai 200031 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Ni","sequence":"additional","affiliation":[{"name":"Shanghai Center for Plant Stress Biology, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences Shanghai 201602 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