{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T20:43:29Z","timestamp":1774644209477,"version":"3.50.1"},"reference-count":70,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,5,31]],"date-time":"2017-05-31T00:00:00Z","timestamp":1496188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005642","name":"Universit\u00e0 degli Studi di Sassari","doi-asserted-by":"publisher","award":["P.O.R. SARDEGNA F.S.E. 2007\u20132013"],"award-info":[{"award-number":["P.O.R. SARDEGNA F.S.E. 2007\u20132013"]}],"id":[{"id":"10.13039\/501100005642","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bsppjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Plant Pathology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Fusarium culmorum<\/jats:italic>\n                    is a soil\u2010borne fungal pathogen which causes foot and root rot and Fusarium head blight on small\u2010grain cereals, in particular wheat and barley. It causes significant yield and quality losses and results in the contamination of kernels with type B trichothecene mycotoxins. Our knowledge of the pathogenicity factors of this fungus is still limited. A transposon tagging approach based on the\n                    <jats:italic>mimp1\/impala<\/jats:italic>\n                    double\u2010component system has allowed us to select a mutant altered in multiple metabolic and morphological processes, trichothecene production and virulence. The flanking regions of\n                    <jats:italic>mimp1<\/jats:italic>\n                    were used to seek homologies in the\n                    <jats:italic>F. culmorum<\/jats:italic>\n                    genome, and revealed that\n                    <jats:italic>mimp1<\/jats:italic>\n                    had reinserted within the last exon of a gene encoding a hypothetical protein of 318 amino acids which contains a ROGDI\u2010like leucine zipper domain, supposedly playing a protein\u2013protein interaction or regulatory role. By functional complementation and bioinformatic analysis, we characterized the gene as the yeast Rav2 homologue, confirming the high level of divergence in multicellular fungi. Deletion of\n                    <jats:italic>FcRav2<\/jats:italic>\n                    or its orthologous gene in\n                    <jats:italic>F. graminearum<\/jats:italic>\n                    highlighted its ability to influence a number of functions, including virulence, trichothecene type B biosynthesis, resistance to azoles and resistance to osmotic and oxidative stress. Our results indicate that the FcRav2 protein (and possibly the RAVE complex as a whole) may become a suitable target for new antifungal drug development or the plant\u2010mediated resistance response in filamentous fungi of agricultural interest.\n                  <\/jats:p>","DOI":"10.1111\/mpp.12551","type":"journal-article","created":{"date-parts":[[2017,3,21]],"date-time":"2017-03-21T12:22:26Z","timestamp":1490098946000},"page":"677-688","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["<i>FcRav2<\/i>\n                    , a gene with a ROGDI domain involved in Fusarium head blight and crown rot on durum wheat caused by\n                    <i>Fusarium culmorum<\/i>"],"prefix":"10.1111","volume":"19","author":[{"given":"Francesca","family":"Spanu","sequence":"first","affiliation":[{"name":"Dipartimento di Agraria Universit\u00e0 degli Studi di Sassari Sassari I\u201007100 Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Scherm","sequence":"additional","affiliation":[{"name":"Dipartimento di Agraria Universit\u00e0 degli Studi di Sassari Sassari I\u201007100 Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Camboni","sequence":"additional","affiliation":[{"name":"Dipartimento di Agraria Universit\u00e0 degli Studi di Sassari Sassari I\u201007100 Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virgilio","family":"Balmas","sequence":"additional","affiliation":[{"name":"Dipartimento di Agraria Universit\u00e0 degli Studi di Sassari Sassari I\u201007100 Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Pani","sequence":"additional","affiliation":[{"name":"Dipartimento di Agraria Universit\u00e0 degli Studi di Sassari Sassari I\u201007100 Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Safa","family":"Oufensou","sequence":"additional","affiliation":[{"name":"Dipartimento di Agraria Universit\u00e0 degli Studi di Sassari Sassari I\u201007100 Italy"},{"name":"Facult\u00e9 des Sciences de Bizerte Zarzouna TN\u20107000 Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolo\u2019","family":"Macciotta","sequence":"additional","affiliation":[{"name":"Dipartimento di Agraria Universit\u00e0 degli Studi di Sassari Sassari I\u201007100 Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matias","family":"Pasquali","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze per gli Alimenti la Nutrizione, l'Ambiente Universit\u00e0 di Milano Milano I\u201020133 Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2459-5833","authenticated-orcid":false,"given":"Quirico","family":"Migheli","sequence":"additional","affiliation":[{"name":"Dipartimento di Agraria Universit\u00e0 degli Studi di Sassari Sassari I\u201007100 Italy"},{"name":"Unit\u00e0 di Ricerca Istituto Nazionale di Biostrutture e Biosistemi Sassari I\u201007100 Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,31]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI-23-5-0566"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-12-52"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2008.00659.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fgb.2011.03.001"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067804"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1094\/PHYTO-99-4-0441"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr938"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00037-08"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(03)00064-2"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10658-011-9749-7"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2012.11.004"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.106.064360"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fgb.2008.09.004"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-1356(02)00203-9"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.12.009"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.funbio.2012.11.001"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fgb.2009.04.004"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI-22-12-1588"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1364-3703.2004.00252.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fgb.2006.01.005"},{"key":"e_1_2_6_22_1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3389\/fphar.2014.00004","article-title":"Advances in targeting the vacuolar proton\u2010translocating ATPase (V\u2010ATPase) for anti\u2010fungal therapy","volume":"5","author":"Hayek S.R.","year":"2014","journal-title":"Front. Pharmacol."},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jib.32"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2008.06395.x"},{"key":"e_1_2_6_25_1","first-page":"166","article-title":"Tmbase \u2013 a database of membrane spanning proteins segments","volume":"374","author":"Hoffmann K.","year":"1993","journal-title":"Biol. Chem. H\u2010S."},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm259"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002940050537"},{"key":"e_1_2_6_28_1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s00107-002-0344-7","article-title":"Upgrading of spruce wood with ethanolamine treatment","volume":"61","author":"Humar M.","year":"2003","journal-title":"Eur. J. Wood Wood Prod."},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm796"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1364-3703.2009.00598.x"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2012.085"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.70.1.177-191.2006"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1364-3703.2011.00762.x"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M608526200"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.075333-0"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI-03-10-0075"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-092412-155650"},{"key":"e_1_2_6_38_1","first-page":"195","article-title":"Influence of soil temperature and moisture on infection of wheat seedlings by Helminthosporium sativum","volume":"26","author":"McKinney H.H.","year":"1923","journal-title":"J. Agric. Res."},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.26807-0"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063077"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.69.2.313"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1128\/genomeA.00670-13"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI-04-13-0125-R"},{"key":"e_1_2_6_44_1","doi-asserted-by":"crossref","first-page":"14 444","DOI":"10.1038\/ncomms14444","article-title":"Innovation and constraint leading to complex multicellularity in the Ascomycota","volume":"8","author":"Nguyen T.A.","year":"2017","journal-title":"Nat. Commun."},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.605"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf500647h"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00050-14"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057429"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.00406"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.1672"},{"key":"e_1_2_6_51_1","doi-asserted-by":"crossref","first-page":"26 256","DOI":"10.1074\/jbc.M113.494815","article-title":"Essential role for vacuolar acidification in Candida albicans virulence","volume":"288","author":"Patenaude C.","year":"2013","journal-title":"J. Biol. Chem."},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2015.01234"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010168"},{"key":"e_1_2_6_54_1","volume-title":"SAS\/STAT Version 9.2","author":"SAS Institute","year":"2008"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1364-3703.2011.00709.x"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/mpp.12011"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/35070067"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppa.12203"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmpp.2004.09.005"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E13-05-0231"},{"key":"e_1_2_6_61_1","doi-asserted-by":"crossref","first-page":"27 511","DOI":"10.1074\/jbc.M115.667634","article-title":"Molecular interactions and cellular itinerary of the yeast RAVE (regulator of the H+\u2010ATPase of vacuolar and endosomal membranes) complex","volume":"290","author":"Smardon A.M.","year":"2015","journal-title":"J. Biol. Chem."},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku1203"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1364-3703.2012.00823.x"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/gbe\/evv092"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppa.12280"},{"key":"e_1_2_6_66_1","first-page":"179","article-title":"Influence of L\u2010sorbose on the growth and morphology of Neurospora crassa","volume":"78","author":"Trinci A.P.J.","year":"1973","journal-title":"Microbiology"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1128\/genomeA.00771-16"},{"key":"e_1_2_6_68_1","first-page":"42","article-title":"A convenient growth medium for Neurospora (Medium N)","volume":"13","author":"Vogel H.J.","year":"1956","journal-title":"Microb. Genet. Bull."},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cropro.2006.09.003"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-phyto-080508-081737"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000939"}],"container-title":["Molecular Plant Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fmpp.12551","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bsppjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/mpp.12551","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T16:49:34Z","timestamp":1762274974000},"score":1,"resource":{"primary":{"URL":"https:\/\/bsppjournals.onlinelibrary.wiley.com\/doi\/10.1111\/mpp.12551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,31]]},"references-count":70,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1111\/mpp.12551"],"URL":"https:\/\/doi.org\/10.1111\/mpp.12551","archive":["Portico"],"relation":{},"ISSN":["1464-6722","1364-3703"],"issn-type":[{"value":"1464-6722","type":"print"},{"value":"1364-3703","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,31]]},"assertion":[{"value":"2016-11-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-03-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-05-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}