{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T08:47:41Z","timestamp":1773564461741,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T00:00:00Z","timestamp":1518134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001364","name":"University of Florida Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001364","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bsppjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Plant Pathology"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    With few exceptions, thaxtomin A (ThxA), a nitrated diketopiperazine, is the pathogenicity determinant for plant\u2010pathogenic\n                    <jats:italic>Streptomyces<\/jats:italic>\n                    species. In\n                    <jats:italic>Streptomyces scabiei<\/jats:italic>\n                    (syn\n                    <jats:italic>. S.\u00a0scabies<\/jats:italic>\n                    ), the ThxA biosynthetic cluster is located within a 177\u2010kb mobile pathogenicity island (PAI), called the toxicogenic region (TR). In\n                    <jats:italic>S.\u00a0turgidiscabies<\/jats:italic>\n                    , the ThxA biosynthetic cluster is located within a 674\u2010kb pathogenicity island (PAIst). The emergence of new plant pathogens occurs in this genus, but not frequently. This raises the question of whether the mobilization of these pathogenicity regions, through mating, is widespread and whether TR and PAIst can confer plant pathogenicity. We showed that ThxA biosynthetic clusters on TR and PAIst were transferred into strains from five non\u2010pathogenic\n                    <jats:italic>Streptomyces<\/jats:italic>\n                    species through mating with\n                    <jats:italic>S.\u00a0scabiei<\/jats:italic>\n                    and\n                    <jats:italic>S.\u00a0turgidiscabies<\/jats:italic>\n                    . However, not all of the transconjugants produced ThxA and exhibited the virulence phenotype, indicating that the genetic background of the recipient strains affects the functionality of the ThxA biosynthetic cluster and therefore would be expected to affect the emergence of novel pathogenic\n                    <jats:italic>Streptomyces<\/jats:italic>\n                    species. Thxs have been patented as natural herbicides, but have yet to be commercialized. Our results also demonstrated the potential of the heterologous production of ThxA as a natural and biodegradable herbicide in non\u2010pathogenic\n                    <jats:italic>Streptomyces<\/jats:italic>\n                    species.\n                  <\/jats:p>","DOI":"10.1111\/mpp.12656","type":"journal-article","created":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T07:54:24Z","timestamp":1515570864000},"page":"1733-1741","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Genetic background affects pathogenicity island function and pathogen emergence in\n                    <i>Streptomyces<\/i>"],"prefix":"10.1111","volume":"19","author":[{"given":"Yucheng","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Plant Pathology University of Florida Gainesville FL 32611 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangde","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry University of Florida Gainesville FL 32610 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yousong","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry University of Florida Gainesville FL 32610 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosemary","family":"Loria","sequence":"additional","affiliation":[{"name":"Department of Plant Pathology University of Florida Gainesville FL 32611 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1048"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/417141a"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2005.02.016"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI-02-14-0037-R"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jam.12369"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jxb\/ern344"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI.1998.11.10.960"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/mpp.12296"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02018-14"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1006\/pmpp.2001.0371"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI-03-11-0073"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2000.02170.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.184.7.2019-2029.2002"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.420182"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0099345"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmpp.2007.09.003"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2009.06780.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2007.05942.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02504"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2004.04461.x"},{"key":"e_1_2_6_22_1","volume-title":"Practical Streptomyces Genetics","author":"Kieser T.","year":"2000"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2009.04.013"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9422(95)00256-7"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf0012998"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(03)00465-5"},{"key":"e_1_2_6_27_1","unstructured":"Koivunen M. 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