{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T18:57:25Z","timestamp":1784660245938,"version":"3.55.0"},"reference-count":70,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T00:00:00Z","timestamp":1531958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31760067"],"award-info":[{"award-number":["31760067"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005693","name":"Hainan University","doi-asserted-by":"publisher","award":["kyqd1531"],"award-info":[{"award-number":["kyqd1531"]}],"id":[{"id":"10.13039\/501100005693","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bsppjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Plant Pathology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    As the terminal components of signal transduction, heat stress transcription factors (Hsfs) mediate the activation of multiple genes responsive to various stresses. However, the information and functional analysis are very limited in non\u2010model plants, especially in cassava (\n                    <jats:italic>Manihot esculenta<\/jats:italic>\n                    ), one of the most important crops in tropical areas. In this study, 32\n                    <jats:italic>MeHsf<\/jats:italic>\n                    s were identified from the cassava genome; the evolutionary tree, gene structures and motifs were also analysed. Gene expression analysis found that\n                    <jats:italic>MeHsf<\/jats:italic>\n                    s were commonly regulated by\n                    <jats:italic>Xanthomonas axonopodis<\/jats:italic>\n                    pv.\n                    <jats:italic>manihotis<\/jats:italic>\n                    (\n                    <jats:italic>Xam<\/jats:italic>\n                    ). Amongst these MeHsfs, MeHsf3 was specifically located in the cell nucleus and showed transcriptionally activated activity on heat stress elements (HSEs). Through transient expression in\n                    <jats:italic>Nicotiana benthamiana<\/jats:italic>\n                    leaves and virus\u2010induced gene silencing (VIGS) in cassava, we identified the essential role of\n                    <jats:italic>MeHsf3<\/jats:italic>\n                    in plant disease resistance, by regulating the transcripts of\n                    <jats:italic>Enhanced Disease Susceptibility 1<\/jats:italic>\n                    (\n                    <jats:italic>EDS1<\/jats:italic>\n                    ) and\n                    <jats:italic>pathogen\u2010related gene 4<\/jats:italic>\n                    (\n                    <jats:italic>PR4<\/jats:italic>\n                    ). Notably, as regulators of defence susceptibility,\n                    <jats:italic>MeEDS1<\/jats:italic>\n                    and\n                    <jats:italic>MePR4<\/jats:italic>\n                    were identified as direct targets of MeHsf3. Moreover, the disease sensitivity of\n                    <jats:italic>MeHsf3\u2010<\/jats:italic>\n                    and\n                    <jats:italic>MeEDS1\u2010<\/jats:italic>\n                    silenced plants could be restored by exogenous salicylic acid (SA) treatment. Taken together, this study highlights the involvement of\n                    <jats:italic>MeHsf3<\/jats:italic>\n                    in defence resistance through the transcriptional activation of\n                    <jats:italic>MeEDS1<\/jats:italic>\n                    and\n                    <jats:italic>MePR4<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/mpp.12691","type":"journal-article","created":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T12:15:29Z","timestamp":1523880929000},"page":"2209-2220","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Heat shock transcription factor 3 regulates plant immune response through modulation of salicylic acid accumulation and signalling in cassava"],"prefix":"10.1111","volume":"19","author":[{"given":"Yunxie","family":"Wei","sequence":"first","affiliation":[{"name":"Hainan Key Laboratory for Sustainable Utilization of Tropical Bioresources Institute of Tropical Agriculture and Forestry, Hainan University  Haikou 570228 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoyin","family":"Liu","sequence":"additional","affiliation":[{"name":"Hainan Key Laboratory for Sustainable Utilization of Tropical Bioresources Institute of Tropical Agriculture and Forestry, Hainan University  Haikou 570228 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Chang","sequence":"additional","affiliation":[{"name":"Hainan Key Laboratory for Sustainable Utilization of Tropical Bioresources Institute of Tropical Agriculture and Forestry, Hainan University  Haikou 570228 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaozu","family":"He","sequence":"additional","affiliation":[{"name":"Hainan Key Laboratory for Sustainable Utilization of Tropical Bioresources Institute of Tropical Agriculture and Forestry, Hainan University  Haikou 570228 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