{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T10:28:40Z","timestamp":1785839320854,"version":"3.56.0"},"reference-count":43,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T00:00:00Z","timestamp":1555977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31772239"],"award-info":[{"award-number":["31772239"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bsppjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Plant Pathology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    AGD2\u2010LIKE DEFENCE RESPONSE PROTEIN 1 (ALD1) triggers plant defence against bacterial and fungal pathogens by regulating the salicylic acid (SA) pathway and an unknown SA\u2010independent pathway. We now show that\n                    <jats:italic>Nicotiana benthamiana ALD1<\/jats:italic>\n                    is involved in defence against a virus and that the ethylene pathway also participates in\n                    <jats:italic>ALD1<\/jats:italic>\n                    \u2010mediated resistance.\n                    <jats:italic>NbALD1<\/jats:italic>\n                    was up\u2010regulated in plants infected with turnip mosaic virus (TuMV). Silencing of\n                    <jats:italic>NbALD1<\/jats:italic>\n                    facilitated TuMV infection, while overexpression of\n                    <jats:italic>NbALD1<\/jats:italic>\n                    or exogenous application of pipecolic acid (Pip), the downstream product of\n                    <jats:italic>ALD1<\/jats:italic>\n                    , enhanced resistance to TuMV. The SA content was lower in\n                    <jats:italic>NbALD1<\/jats:italic>\n                    \u2010silenced plants and higher where\n                    <jats:italic>NbALD1<\/jats:italic>\n                    was overexpressed or following Pip treatments. SA mediated resistance to TuMV and was required for\n                    <jats:italic>NbALD1<\/jats:italic>\n                    \u2010mediated resistance. However, on\n                    <jats:italic>NahG<\/jats:italic>\n                    plants (in which SA cannot accumulate), Pip treatment still alleviated susceptibility to TuMV, further demonstrating the presence of an SA\u2010independent resistance pathway. The ethylene precursor, 1\u2010aminocyclopropanecarboxylic acid (ACC), accumulated in\n                    <jats:italic>NbALD1<\/jats:italic>\n                    \u2010silenced plants but was reduced in plants overexpressing\n                    <jats:italic>NbALD1<\/jats:italic>\n                    or treated with Pip. Silencing of\n                    <jats:italic>ACS1<\/jats:italic>\n                    , a key gene in the ethylene pathway, alleviated the susceptibility of\n                    <jats:italic>NbALD1<\/jats:italic>\n                    \u2010silenced plants to TuMV, while exogenous application of ACC compromised the resistance of Pip\u2010treated or\n                    <jats:italic>NbALD1<\/jats:italic>\n                    transgenic plants. The results indicate that\n                    <jats:italic>NbALD1<\/jats:italic>\n                    mediates resistance to TuMV by positively regulating the resistant SA pathway and negatively regulating the susceptible ethylene pathway.\n                  <\/jats:p>","DOI":"10.1111\/mpp.12808","type":"journal-article","created":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T07:18:13Z","timestamp":1556003893000},"page":"990-1004","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["<i>NbALD1<\/i>\n                    mediates resistance to turnip mosaic virus by regulating the accumulation of salicylic acid and the ethylene pathway in\n                    <i>Nicotiana benthamiana<\/i>"],"prefix":"10.1111","volume":"20","author":[{"given":"Shu","family":"Wang","sequence":"first","affiliation":[{"name":"College of Agriculture and Biotechnology Zhejiang University Hangzhou 310058 China"},{"name":"The State Key Laboratory Breeding Base for Sustainable Control of Pest and Disease, Key Laboratory of Biotechnology in Plant Protection of MOA of China and Zhejiang Province, Institute of Virology and Biotechnology Zhejiang Academy of Agricultural Sciences Hangzhou 310021 China"},{"name":"Institute of Plant Virology Ningbo University Ningbo 315211 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelei","family":"Han","sequence":"additional","affiliation":[{"name":"College of Plant Protection Nanjing Agricultural University Nanjing 210095 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiejun","family":"Peng","sequence":"additional","affiliation":[{"name":"Institute of Plant Virology Ningbo University Ningbo 315211 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinping","family":"Zhao","sequence":"additional","affiliation":[{"name":"The State Key Laboratory Breeding Base for Sustainable Control of Pest and Disease, Key Laboratory of 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