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However, plants respond to virus infection through several mechanisms, such as autophagy, ubiquitination, mRNA decay and gene silencing, that target viral components. Viral factors work in synchrony with pro\u2010viral host factors during the infection cycle and are targeted by antiviral responses. Accordingly, establishment of virus infection is genetically determined by the availability of the pro\u2010viral factors necessary for genome replication and movement, and by the balance between plant defence and viral suppression of defence responses. Sequential requirement of pro\u2010viral factors and the antagonistic activity of antiviral factors suggest a two\u2010step model to explain plant\u2013virus interactions. At each step of the infection process, host factors with antiviral activity have been identified. Here we review our current understanding of host factors with antiviral activity against plant viruses.<\/jats:p>","DOI":"10.1111\/mpp.12851","type":"journal-article","created":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T02:09:59Z","timestamp":1562638199000},"page":"1588-1601","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":107,"title":["Host factors against plant viruses"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4681-470X","authenticated-orcid":false,"given":"Hernan","family":"Garcia\u2010Ruiz","sequence":"first","affiliation":[{"name":"Nebraska Center for Virology, Department of Plant Pathology University of Nebraska\u2010Lincoln Lincoln NE 68503 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