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In this research, we identified a negative regulator of plant immunity to the oomycete\n                    <jats:italic>Phytophthora parasitica<\/jats:italic>\n                    ,\n                    <jats:italic>AtRTP5<\/jats:italic>\n                    (\n                    <jats:italic>Arabidopsis thaliana<\/jats:italic>\n                    Resistant to\n                    <jats:italic>Phytophthora<\/jats:italic>\n                    5), which encodes a WD40 repeat domain\u2010containing protein. The AtRTP5 protein, which was\u00a0tagged with green\u00a0fluorescent protein (GFP), is localized in the nucleus and plasma membrane. Both the\n                    <jats:italic>A. thaliana<\/jats:italic>\n                    T\u2010DNA insertion\n                    <jats:italic>rtp5<\/jats:italic>\n                    mutants and the\n                    <jats:italic>Nicotiana benthamiana RTP5<\/jats:italic>\n                    (\n                    <jats:italic>NbRTP5<\/jats:italic>\n                    ) silencing plants showed enhanced resistance to\n                    <jats:italic>P. parasitica<\/jats:italic>\n                    , while overexpression of\n                    <jats:italic>AtRTP5<\/jats:italic>\n                    rendered plants more susceptible. The transcriptomic analysis showed that mutation of\n                    <jats:italic>AtRTP5<\/jats:italic>\n                    suppressed the biosynthesis of endogenous jasmonic acid (JA) and JA\u2010dependent responses. In contrast, salicylic acid (SA) biosynthesis and SA\u2010dependent responses were activated in the T\u2010DNA insertion mutant\n                    <jats:italic>rtp5\u20103<\/jats:italic>\n                    . These results show that\n                    <jats:italic>AtRTP5<\/jats:italic>\n                    acts as a conserved negative regulator of plant immunity to\n                    <jats:italic>Phytophthora<\/jats:italic>\n                    pathogens by interfering with JA and SA signalling pathways.\n                  <\/jats:p>","DOI":"10.1111\/mpp.12883","type":"journal-article","created":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T04:43:02Z","timestamp":1573188182000},"page":"95-108","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["<i>AtRTP5<\/i>\n                    negatively regulates plant resistance to\n                    <i>Phytophthora<\/i>\n                    pathogens by modulating the biosynthesis of endogenous jasmonic acid and salicylic acid"],"prefix":"10.1111","volume":"21","author":[{"given":"Weiwei","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Crop Stress Biology for Arid Areas and College of Plant Protection Northwest A&amp;F University Yangling Shaanxi 712100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Crop Stress Biology for Arid Areas and College of Agronomy Northwest A&amp;F University Yangling Shaanxi 712100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Dong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Crop Stress Biology for Arid Areas and College of Agronomy Northwest A&amp;F University Yangling Shaanxi 712100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianglan","family":"Kong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Crop Stress Biology for Arid Areas and College of Agronomy Northwest A&amp;F University Yangling Shaanxi 712100 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