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We previously identified that copper ion (Cu\n                    <jats:sup>2+<\/jats:sup>\n                    ) acts as an extremely sensitive elicitor to induce ethylene (ET)\u2010dependent immunity in\n                    <jats:italic>Arabidopsis<\/jats:italic>\n                    . Here, we found that Cu\n                    <jats:sup>2+<\/jats:sup>\n                    induces the defence response to\n                    <jats:italic>P.\u00a0infestans<\/jats:italic>\n                    in potato. Cu\n                    <jats:sup>2+<\/jats:sup>\n                    suppresses the transcription of the abscisic acid (ABA) biosynthetic genes\n                    <jats:italic>StABA1<\/jats:italic>\n                    and\n                    <jats:italic>StNCED1<\/jats:italic>\n                    , resulting in decreased ABA content. Treatment with ABA or inhibitor fluridone made potato more susceptible or resistance to late blight, respectively. In addition, potato with knockdown of\n                    <jats:italic>StABA1<\/jats:italic>\n                    or\n                    <jats:italic>StNCED1<\/jats:italic>\n                    showed greater resistance to late blight, suggesting that ABA negatively regulates potato resistance to\n                    <jats:italic>P.\u00a0infestans<\/jats:italic>\n                    . Cu\n                    <jats:sup>2+<\/jats:sup>\n                    also promotes the rapid biosynthesis of ET. Potato plants treated with 1\u2010aminocyclopropane\u20101\u2010carboxylate showed enhanced resistance to late blight. Repressed expression of\n                    <jats:italic>StEIN2<\/jats:italic>\n                    or\n                    <jats:italic>StEIN3<\/jats:italic>\n                    resulted in enhanced transcription of\n                    <jats:italic>StABA1<\/jats:italic>\n                    and\n                    <jats:italic>StNCED1<\/jats:italic>\n                    , accumulation of ABA and susceptibility to\n                    <jats:italic>P.\u00a0infestans<\/jats:italic>\n                    . Consistently, StEIN3 directly binds to the promoter regions of\n                    <jats:italic>StABA1<\/jats:italic>\n                    and\n                    <jats:italic>StNCED1<\/jats:italic>\n                    . Overall, we concluded that Cu\n                    <jats:sup>2+<\/jats:sup>\n                    triggers the defence response to potato late blight by activating ET biosynthesis to inhibit the biosynthesis of ABA.\n                  <\/jats:p>","DOI":"10.1111\/mpp.12919","type":"journal-article","created":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T20:59:09Z","timestamp":1582145949000},"page":"636-651","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Copper ions suppress abscisic acid biosynthesis to enhance defence against\n                    <i>Phytophthora infestans<\/i>\n                    in potato"],"prefix":"10.1111","volume":"21","author":[{"given":"Hai\u2010Feng","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Crop Biology College of Agronomy Shandong Agricultural University Tai an Shandong PR 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College of Plant Protection Shandong Agricultural University Tai an Shandong PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan\u2010Lin","family":"Meng","sequence":"additional","affiliation":[{"name":"Shandong Provincial Key Laboratory for Biology of Vegetable Diseases and Insect Pests College of Plant Protection Shandong Agricultural University Tai an Shandong PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao\u2010Gang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shandong Provincial Key Laboratory for Biology of Vegetable Diseases and Insect Pests College of Plant Protection Shandong Agricultural University Tai an Shandong PR China"},{"name":"Vector\u2010borne Virus Research Center State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops Fujian Agriculture and Forestry University Fuzhou Fujian PR 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