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However, the mechanisms involved in such regulatory effects remain largely uncharacterized. To provide more insight into the mechanisms whereby temperature regulates plant\u2013virus interactions, we analysed changes in the proteome of potato cv. Chicago plants infected with potato virus Y (PVY) at normal (22\u00a0\u00b0C) and elevated temperature (28\u00a0\u00b0C), which is known to significantly increase plant susceptibility to the virus. One of the most intriguing findings is that the main enzymes of the methionine cycle (MTC) were down\u2010regulated at the higher but not at normal temperatures. With good agreement, we found that higher temperature conditions triggered consistent and concerted changes in the level of MTC metabolites, suggesting that the enhanced susceptibility of potato plants to PVY at 28\u00a0\u00b0C may at least be partially orchestrated by the down\u2010regulation of MTC enzymes and concomitant cycle perturbation. In line with this, foliar treatment of these plants with methionine restored accumulation of MTC metabolites and subverted the susceptibility to PVY at elevated temperature. These data are discussed in the context of the major function of the MTC in transmethylation processes.<\/jats:p>","DOI":"10.1111\/mpp.13009","type":"journal-article","created":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T13:11:45Z","timestamp":1604495505000},"page":"77-91","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Role of the methionine cycle in the temperature\u2010sensitive responses of potato plants to potato virus Y"],"prefix":"10.1111","volume":"22","author":[{"given":"Igor","family":"Fesenko","sequence":"first","affiliation":[{"name":"Shemyakin\u2010Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences Moscow Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadezhda","family":"Spechenkova","sequence":"additional","affiliation":[{"name":"Shemyakin\u2010Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences Moscow Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Mamaeva","sequence":"additional","affiliation":[{"name":"Shemyakin\u2010Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences Moscow Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonida V.","family":"Makhotenko","sequence":"additional","affiliation":[{"name":"Shemyakin\u2010Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences Moscow Russian Federation"},{"name":"Belozersky Institute of Physico\u2010chemical Biology Lomonosov Moscow State University Moscow Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Love","sequence":"additional","affiliation":[{"name":"The James Hutton Institute Invergowrie, Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia O.","family":"Kalinina","sequence":"additional","affiliation":[{"name":"Shemyakin\u2010Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences Moscow Russian Federation"},{"name":"Belozersky Institute of Physico\u2010chemical Biology Lomonosov Moscow State University Moscow Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6499-6439","authenticated-orcid":false,"given":"Michael","family":"Taliansky","sequence":"additional","affiliation":[{"name":"Shemyakin\u2010Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences Moscow Russian Federation"},{"name":"The James Hutton Institute Invergowrie, Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2006.02861.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/mpp.12204"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep19715"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029009"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2005.04.012"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10681-005-3881-4"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI-02-13-0037-R"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.aivir.2018.06.004"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.105.066563"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msaa091"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2015.02.028"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9452(01)00521-0"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2824"},{"key":"e_1_2_8_15_1","first-page":"9","volume-title":"Plant Proteomics. 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