{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T14:48:22Z","timestamp":1791470902298,"version":"4.3.4"},"reference-count":104,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T00:00:00Z","timestamp":1607558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["BIO2017\u201388321\u2010R"],"award-info":[{"award-number":["BIO2017\u201388321\u2010R"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["BIO2017\u201388321\u2010R"],"award-info":[{"award-number":["BIO2017\u201388321\u2010R"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["AGL2016\u201079825\u2010R"],"award-info":[{"award-number":["AGL2016\u201079825\u2010R"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bsppjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Plant Pathology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Taxonomy<\/jats:title><jats:p><jats:italic>Hop stunt viroid<\/jats:italic> (HSVd) is the type species of the genus <jats:italic>Hostuviroid<\/jats:italic> (family <jats:italic>Pospiviroidae<\/jats:italic>). The other species of this genus is <jats:italic>Dahlia latent viroid<\/jats:italic>, which presents an identical central conserved region (CCR) but lacks other structural hallmarks present in <jats:italic>Hop stunt viroid<\/jats:italic>. HSVd replication occurs in the nucleus through an asymmetric rolling\u2010circle model as in the other members of the family <jats:italic>Pospiviroidae<\/jats:italic>, which also includes the genera <jats:italic>Pospiviroid<\/jats:italic>, <jats:italic>Cocadviroid, Apscaviroid<\/jats:italic>, and <jats:italic>Coleoviroid<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Physical properties<\/jats:title><jats:p><jats:italic>Hop stunt viroid<\/jats:italic> consists of a single\u2010stranded, circular RNA of 295\u2013303 nucleotides depending on isolates and sequence variants. The most stable secondary structure is a rod\u2010like or quasi\u2010rod\u2010like conformation with two characteristic domains: a CCR and a terminal conserved hairpin similar to that of cocadviroids. HSVd lacks a terminal conserved region.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hosts and symptoms<\/jats:title><jats:p>HSVd infects a very broad range of natural hosts and has been reported to be the causal agent of five different diseases (citrus cachexia, cucumber pale fruit, peach and plum apple apricot distortion, and hop stunt). It is distributed worldwide.<\/jats:p><\/jats:sec><jats:sec><jats:title>Transmission<\/jats:title><jats:p>HSVd is transmitted mechanically and by seed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/mpp.13022","type":"journal-article","created":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T01:37:12Z","timestamp":1607650632000},"page":"153-162","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Hop stunt viroid: A polyphagous pathogenic RNA that has shed light on viroid\u2013host interactions"],"prefix":"10.1111","volume":"22","author":[{"given":"Joan","family":"Marquez\u2010Molins","sequence":"first","affiliation":[{"name":"Institute for Integrative Systems Biology (I2SysBio) Consejo Superior de Investigaciones Cient\u00edficas, Universitat de Val\u00e8ncia Paterna Spain"},{"name":"Instituto de Biolog\u00eda Molecular y Celular de Plantas Consejo Superior de Investigaciones Cient\u00edficas, Universitat Polit\u00e8cnica de Val\u00e8ncia Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Gomez","sequence":"additional","affiliation":[{"name":"Institute for Integrative Systems Biology (I2SysBio) Consejo Superior de Investigaciones Cient\u00edficas, Universitat de Val\u00e8ncia Paterna Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4954-989X","authenticated-orcid":false,"given":"Vicente","family":"Pallas","sequence":"additional","affiliation":[{"name":"Instituto de Biolog\u00eda Molecular y Celular de Plantas Consejo Superior de Investigaciones Cient\u00edficas, Universitat Polit\u00e8cnica de Val\u00e8ncia Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,10]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"e1570","DOI":"10.1002\/wrna.1570","article-title":"Current overview on viroid\u2013host interactions","volume":"11","author":"Adkar\u2010Purushothama C.R.","year":"2019","journal-title":"WIREs RNA"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/v11040345"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.17660\/ActaHortic.2001.550.45"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-82-4-953"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10658-007-9127-7"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01877053"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.000154"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-313X.1996.09040457.x"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.17660\/ActaHortic.1998.472.77"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008794531725"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppa.12358"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jxb\/erw353"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/nph.14001"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/v11050425"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401090101"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/v10110612"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-014-2200-6"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02336-09"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/277060a0"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-phyto-080508-081927"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-801498-1.00012-7"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01980613"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1914110"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1094\/PHP-2007-1127-01-RS"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/v1020241"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2004.03.118"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2015.02.027"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1169202"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0030182"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.108.120808"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tplants.2009.03.002"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI.2001.14.7.910"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.18.10104-10110.2004"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1364-3703.2006.00356.x"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2007.04.009"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2007.03203.x"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.112.195214"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2004.02278.x"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3059.2008.01875.x"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-arplant-042916-041139"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-801498-1.00034-6"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10658-008-9420-0"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-801498-1.00019-X"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02339-06"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10658-016-1075-7"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI-03-17-0071-R"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2017.04.002"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008386"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.14.4582"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-78-12-3177"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.3186\/jjphytopath.61.381"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.4161\/psb.19994"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.111.184275"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcp.2013.07.003"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006547"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10658-013-0243-2"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.5197\/j.2044-0588.2013.027.014"},{"key":"e_1_2_12_59_1","first-page":"1","article-title":"Biological and molecular characterization of hop stunt viroid variants from pistachio trees in Iran","volume":"9","author":"Maddahian M.","year":"2019","journal-title":"Journal of Phytopathology"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10658-007-9205-x"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13007-019-0470-4"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt968"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1364-3703.2009.00608.x"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00425424"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/278185a0"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0236481"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007686"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1206187109"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/11.18.6185"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1364-3703.2007.00418.x"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI.2001.14.7.905"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.213.4508.670"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2013.00130"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-801498-1.00035-8"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(87)90260-1"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/29.11.2395"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.016576"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1094\/PDIS-08-11-0640-PDN"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-79-12-3163"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1094\/PHYTO.1999.89.7.568"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(79)90252-3"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.106.049775"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.4161\/gmcr.1.2.11871"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-70-6-1311"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008182302704"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/12.8.3427"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.2183\/pjab.53.109"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-69-12-3059"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2008.08.003"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.4161\/psb.25784"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.aivir.2015.11.002"},{"key":"e_1_2_12_92_1","first-page":"10563","article-title":"Viroid research and its significance for RNA technology and basic biochemistry","volume":"46","author":"Steger G.","year":"2018","journal-title":"Nucleic Acids Research"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-015-0332-2"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.10027"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/jph.12821"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0400104101"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90119-8"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.02427"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1094\/PDIS-08-16-1086-PDN"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1094\/Phyto-82-279"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10528-007-9134-6"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21197383"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10658-012-9983-7"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-82-6-1491"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.006403"}],"container-title":["Molecular Plant Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/mpp.13022","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/mpp.13022","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bsppjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/mpp.13022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:21:28Z","timestamp":1760952088000},"score":1,"resource":{"primary":{"URL":"https:\/\/bsppjournals.onlinelibrary.wiley.com\/doi\/10.1111\/mpp.13022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,10]]},"references-count":104,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1111\/mpp.13022"],"URL":"https:\/\/doi.org\/10.1111\/mpp.13022","archive":["Portico"],"relation":{},"ISSN":["1464-6722","1364-3703"],"issn-type":[{"value":"1464-6722","type":"print"},{"value":"1364-3703","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,10]]},"assertion":[{"value":"2020-10-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}