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However, the roles of these MAPKs in resistance of potato (<jats:italic>Solanum tuberosum<\/jats:italic>) against <jats:italic>Phytophthora<\/jats:italic> pathogens is not well studied. Our previous work showed that a <jats:italic>Phytophthora infestans<\/jats:italic> RXLR effector targets and stabilizes the negative regulator of MAPK kinase 1 of potato (StMKK1). Because in <jats:italic>Arabidopsis thaliana<\/jats:italic> the AtMPK4 is the downstream phosphorylation target of AtMKK1, we performed a phylogenetic analysis and found that potato StMPK4\/6\/7 are closely related and are orthologs of AtMPK4\/5\/11\/12. Overexpression of StMPK4\/7 enhances plant resistance to <jats:italic>P.\u00a0infestans<\/jats:italic> and <jats:italic>P.\u00a0parasitica<\/jats:italic>. Yeast two\u2010hybrid analysis revealed that StMPK7 interacts with StMKK1, and StMPK7 is phosphorylated on flg22 treatment and by expressing constitutively active StMKK1 (CA\u2010StMKK1), indicating that StMPK7 is a direct downstream signalling partner of StMKK1. Overexpression of StMPK7 in potato enhances potato resistance to <jats:italic>P.\u00a0infestans<\/jats:italic>. Constitutively active StMPK7 (CA\u2010StMPK7; StMPK7<jats:sup>D198G, E202A<\/jats:sup>) was found to promote immunity to <jats:italic>Phytophthora<\/jats:italic> pathogens and to trigger host cell death when overexpressed in <jats:italic>Nicotiana benthamiana<\/jats:italic> leaves. Cell death triggered by CA\u2010StMPK7 is SGT1\/RAR1\u2010dependent. Furthermore, cell death triggered by CA\u2010StMPK7 is suppressed on coexpression with the salicylate hydroxylase NahG, and StMPK7 activation promotes salicylic acid (SA)\u2010responsive gene expression. We conclude that potato StMPK7 is a downstream signalling component of the phosphorelay cascade involving StMKK1 and StMPK7 plays a role in immunity to <jats:italic>Phytophthora<\/jats:italic> pathogens via an SA\u2010dependent signalling pathway.<\/jats:p>","DOI":"10.1111\/mpp.13050","type":"journal-article","created":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T05:11:05Z","timestamp":1616649065000},"page":"644-657","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Potato StMPK7 is a downstream component of StMKK1 and promotes resistance to the oomycete pathogen <i>Phytophthora infestans<\/i>"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4800-293X","authenticated-orcid":false,"given":"Houxiao","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Horticulture Northwest A&amp;F University and State Key Laboratory of Crop Stress Biology for Arid Areas 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