{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:43:20Z","timestamp":1790783000699,"version":"4.1.0"},"reference-count":65,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T00:00:00Z","timestamp":1646697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["BT\/09\/IYBA\/2015\/12"],"award-info":[{"award-number":["BT\/09\/IYBA\/2015\/12"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bsppjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Plant Pathology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Powdery mildew (PM) caused by the obligate biotrophic fungal pathogen\n                    <jats:italic>Erysiphe pisi<\/jats:italic>\n                    is an economically important disease of legumes. Legumes are rich in isoflavonoids, a class of secondary metabolites whose role in PM resistance is ambiguous. Here we show that the pterocarpan medicarpin accumulates at fungal infection sites, as analysed by fluorescein\u2010tagged medicarpin, and provides penetration and post\u2010penetration resistance against\n                    <jats:italic>E.\u00a0pisi<\/jats:italic>\n                    in\n                    <jats:italic>Medicago truncatula<\/jats:italic>\n                    in part through the activation of the salicylic acid (SA) signalling pathway. Comparative gene expression and metabolite analyses revealed an early induction of isoflavonoid biosynthesis and accumulation of the defence phytohormones SA and jasmonic acid (JA) in the highly resistant\n                    <jats:italic>M.\u00a0truncatula<\/jats:italic>\n                    genotype A17 but not in moderately susceptible R108 in response to PM infection. Pretreatment of R108 leaves with medicarpin increased SA levels, SA\u2010associated gene expression, and accumulation of hydrogen peroxide at PM infection sites, and reduced fungal penetration and colony formation. Strong parallels in the levels of medicarpin and SA, but not JA, were observed on medicarpin\/SA treatment pre\u2010 or post\u2010PM infection. Collectively, our results suggest that medicarpin and SA may act in concert to restrict\n                    <jats:italic>E.\u00a0pisi<\/jats:italic>\n                    growth, providing new insights into the metabolic and signalling pathways required for PM resistance in legumes.\n                  <\/jats:p>","DOI":"10.1111\/mpp.13202","type":"journal-article","created":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T12:20:59Z","timestamp":1646742059000},"page":"966-983","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Medicarpin confers powdery mildew resistance in\n                    <i>Medicago truncatula<\/i>\n                    and activates the salicylic acid signalling pathway"],"prefix":"10.1111","volume":"23","author":[{"given":"Arunima","family":"Gupta","sequence":"first","affiliation":[{"name":"Laboratory of Plant\u2010Microbe Interactions Regional Centre for Biotechnology NCR Biotech Science Cluster  Faridabad Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pallavi","family":"Awasthi","sequence":"additional","affiliation":[{"name":"Medicinal and Process Chemistry Central Drug Research Institute  Lucknow Uttar Pradesh India"},{"name":"Academy of Scientific and Innovative Research  Ghaziabad Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"Sharma","sequence":"additional","affiliation":[{"name":"Advanced Technology Platform Centre, Regional Centre for Biotechnology  Faridabad Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sajiya","family":"Parveen","sequence":"additional","affiliation":[{"name":"Medicinal and Process Chemistry Central Drug Research Institute  Lucknow Uttar Pradesh India"},{"name":"Academy of Scientific and Innovative Research  Ghaziabad Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi 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