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In this study, a typical\n                    <jats:italic>TOLL\u2010INTERLEUKIN 1 RECEPTOR, NUCLEOTIDE\u2010BINDING, LEUCINE\u2010RICH REPEAT<\/jats:italic>\n                    (\n                    <jats:italic>TIR\u2010NB\u2010LRR<\/jats:italic>\n                    )\u2010encoding gene,\n                    <jats:italic>WHITE RUST RESISTANCE 4<\/jats:italic>\n                    (\n                    <jats:italic>WRR4B<\/jats:italic>\n                    ), was identified to be required for the resistance against\n                    <jats:italic>O. heveae<\/jats:italic>\n                    in\n                    <jats:italic>Arabidopsis<\/jats:italic>\n                    . The expression of\n                    <jats:italic>WRR4B<\/jats:italic>\n                    was upregulated by\n                    <jats:italic>O. heveae<\/jats:italic>\n                    inoculation, and\n                    <jats:italic>WRR4B<\/jats:italic>\n                    positively regulated the expression of genes involved in SA biosynthesis, such as\n                    <jats:italic>EDS1<\/jats:italic>\n                    ,\n                    <jats:italic>PAD4<\/jats:italic>\n                    ,\n                    <jats:italic>ICS1<\/jats:italic>\n                    (\n                    <jats:italic>ISOCHORISMATE SYNTHASE 1<\/jats:italic>\n                    ),\n                    <jats:italic>SARD1<\/jats:italic>\n                    (\n                    <jats:italic>SYSTEMIC\u2010ACQUIRED RESISTANCE DEFICIENT 1<\/jats:italic>\n                    ) and\n                    <jats:italic>CBP60g<\/jats:italic>\n                    (\n                    <jats:italic>CALMODULIN\u2010BINDING PROTEIN 60\u2009G<\/jats:italic>\n                    ). Furthermore, WRR4B triggered self\u2010amplification, suggesting that WRR4B mediated plant resistance through taking part in the SA\u2010based positive feedback loop. In addition, WRR4B induced an\n                    <jats:italic>EDS1<\/jats:italic>\n                    \u2010dependent hypersensitive response in\n                    <jats:italic>Nicotiana benthamiana<\/jats:italic>\n                    and contributed to disease resistance against three other PM species:\n                    <jats:italic>Podosphaera xanthii<\/jats:italic>\n                    ,\n                    <jats:italic>Erysiphe quercicola<\/jats:italic>\n                    and\n                    <jats:italic>Erysiphe neolycopersici<\/jats:italic>\n                    , indicating that\n                    <jats:italic>WRR4B<\/jats:italic>\n                    is a broad\u2010spectrum disease resistance gene against PMs.\n                  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