{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:02:53Z","timestamp":1792180973289,"version":"4.4.0"},"reference-count":77,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["2018\u201005155"],"award-info":[{"award-number":["2018\u201005155"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bsppjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Plant Pathology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The soil\u2010dwelling bacterium\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Streptomyces scabiei<\/jats:italic>\n                    <\/jats:styled-content>\n                    is distributed worldwide and is the best\u2010characterised causative agent of common scab disease, which impacts potato crops and causes significant economic losses to growers. The principal pathogenicity factor responsible for common scab development is the phytotoxin thaxtomin A, which functions as a cellulose biosynthesis inhibitor in plants.\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>S. scabiei<\/jats:italic>\n                    <\/jats:styled-content>\n                    also produces polyketide compounds belonging to the concanamycin family, which serve as inhibitors of eukaryotic vacuolar\u2010type ATPases and have been shown to exhibit phytotoxic activity against different plant species. It has been proposed that concanamycins contribute to the virulence of\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">S. scabiei<\/jats:styled-content>\n                      ,\n                    <\/jats:italic>\n                    but direct evidence of this has been lacking. Using constructed strains of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>S. scabiei<\/jats:italic>\n                    <\/jats:styled-content>\n                    that are either unable to produce concanamycins or produce elevated levels of the metabolites, we showed that concanamycins enhance the severity of disease symptoms induced by\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>S. scabiei<\/jats:italic>\n                    <\/jats:styled-content>\n                    on radish seedlings and potato tuber tissue. We demonstrated that concanamycin production is controlled by two regulatory genes that are situated within the concanamycin biosynthetic gene cluster, and that production of concanamycins and thaxtomin A by\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>S. scabiei<\/jats:italic>\n                    <\/jats:styled-content>\n                    is modulated by different nutritional signals. The concanamycin biosynthetic gene cluster is conserved in other common scab\u2010causing\n                    <jats:italic>Streptomyces<\/jats:italic>\n                    spp., suggesting that these metabolites may function as important virulence determinants in multiple phytopathogenic species. Overall, this study expands our understanding of the molecular factors that enable plant host colonisation and common scab disease development by\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">S. scabiei<\/jats:styled-content>\n                      .\n                    <\/jats:italic>\n                  <\/jats:p>","DOI":"10.1111\/mpp.70175","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T09:42:11Z","timestamp":1764150131000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Concanamycins Are Key Contributors to the Virulence of the Potato Common Scab Pathogen\n                    <scp>\n                      <i>Streptomyces scabiei<\/i>\n                    <\/scp>"],"prefix":"10.1111","volume":"26","author":[{"given":"Corrie V.","family":"Vincent","sequence":"first","affiliation":[{"name":"Department of Biology Memorial University of Newfoundland  St. John's Newfoundland and Labrador Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1731-5669","authenticated-orcid":false,"given":"Dawn R. 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