{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T21:43:51Z","timestamp":1788299031528,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T00:00:00Z","timestamp":1768089600000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bsppjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Plant Pathology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Grapevine, as an important economic crop around the world, has generally poor disease resistance in planting.\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Vitis vinifera<\/jats:italic>\n                    <\/jats:styled-content>\n                    , in particular, show high susceptibility to grey mould (caused by\n                    <jats:italic>Botrytis cinerea<\/jats:italic>\n                    ), which leads to a decline in yield and quality. Existing chemical control methods have limitations, including environmental and resistance issues, so breeding disease\u2010resistant varieties is crucial for sustainable agriculture. In this study, we identified a nuclear membrane\u2010localised R2R3\u2010type MYB transcription factor named VlMYB149 whose expression was significantly upregulated following grey mould infection. Overexpression of\n                    <jats:italic>VlMYB149<\/jats:italic>\n                    in grapevine and\n                    <jats:italic>Arabidopsis<\/jats:italic>\n                    indicated that it significantly enhances resistance to grey mould, characterised by reduced lesion size and inhibited mycelial expansion.\n                    <jats:italic>VlMYB149<\/jats:italic>\n                    increased the content of copper and increased the activities of antioxidant enzymes such as catalase (CAT), peroxidase (POD) and superoxide dismutase (SOD). VlMYB149 also directly activated the expression of\n                    <jats:italic>VlHIPP30<\/jats:italic>\n                    , which plays a crucial role in the process of copper transport. Overexpression of\n                    <jats:italic>VlHIPP30<\/jats:italic>\n                    has been shown to enhance disease resistance by reducing reactive oxygen species (ROS) levels and enhancing copper metabolism. Our findings reveal a novel molecular mechanism model for grapevine resistance to\n                    <jats:italic>B. cinerea<\/jats:italic>\n                    , mediated by the synergistic interaction by copper metabolism and the antioxidant system. This study not only provides crucial genetic resources for breeding disease\u2010resistant crops but also advances our fundamental understanding of plant immunity.\n                  <\/jats:p>","DOI":"10.1111\/mpp.70197","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T04:10:46Z","timestamp":1768191046000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The\n                    <scp>VlMYB149<\/scp>\n                    \u2010\n                    <scp>VlHIPP30<\/scp>\n                    Regulatory Module Enhances Grapevine Resistance to\n                    <i>Botrytis cinerea<\/i>\n                    by Activating the Antioxidant System and Copper Metabolism"],"prefix":"10.1111","volume":"27","author":[{"given":"Xiaoli","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Horticulture Shenyang Agricultural University  Shenyang Liaoning 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