{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:58:07Z","timestamp":1789675087060,"version":"4.0.1"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2023QC135"],"award-info":[{"award-number":["ZR2023QC135"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32302322"],"award-info":[{"award-number":["32302322"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32472523"],"award-info":[{"award-number":["32472523"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M751874"],"award-info":[{"award-number":["2024M751874"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bsppjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Plant Pathology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Tomato brown rugose fruit virus (ToBRFV) overcomes Tm\u20102\n                    <jats:sup>2<\/jats:sup>\n                    \u2010mediated resistance, posing a serious threat to global tomato production. We previously identified that key residues in the movement protein (MP)\u2010H67, N125, K129, A134, I147 and I168 are essential for ToBRFV evasion of Tm\u20102\n                    <jats:sup>2<\/jats:sup>\n                    resistance. However, the underlying mechanisms remain unclear. In\n                    <jats:italic>Tm\u20102<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>2<\/jats:italic>\n                    <\/jats:sup>\n                    \u2010transgenic\n                    <jats:italic>Nicotiana benthamiana<\/jats:italic>\n                    plants at later infection stages, MP mutations H67C, N125A, K129Q and A134N abolished ToBRFV\u2010GFP cell\u2010to\u2010cell and systemic movement, whereas I168N abolished ToBRFV\u2010GFP systemic but not cell\u2010to\u2010cell movement, and I147M partially impaired both. Correspondingly, the MP\n                    <jats:sup>H67C<\/jats:sup>\n                    , MP\n                    <jats:sup>N125A<\/jats:sup>\n                    , MP\n                    <jats:sup>K129Q<\/jats:sup>\n                    and MP\n                    <jats:sup>A134N<\/jats:sup>\n                    mutants elicited strong\n                    <jats:italic>Tm\u20102<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>2<\/jats:italic>\n                    <\/jats:sup>\n                    \u2010mediated hypersensitive response (HR), MP\n                    <jats:sup>I168N<\/jats:sup>\n                    elicited mild HR and MP\n                    <jats:sup>I147M<\/jats:sup>\n                    elicited none. Confocal microscopy revealed I147M reduced MP localisation at plasmodesmata in\n                    <jats:italic>Tm\u20102<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>2<\/jats:italic>\n                    <\/jats:sup>\n                    \u2010transgenic\n                    <jats:italic>N.\u2009benthamiana<\/jats:italic>\n                    leaves. The interaction with Tm\u20102\n                    <jats:sup>2<\/jats:sup>\n                    was weak for wild\u2010type MP and I147M (slightly enhanced), but moderately or strongly enhanced for I168N and the other four mutants. Wild\u2010type MP and MP\n                    <jats:sup>I147M<\/jats:sup>\n                    failed to induce Tm\u20102\n                    <jats:sup>2<\/jats:sup>\n                    self\u2010association, MP\n                    <jats:sup>I168N<\/jats:sup>\n                    only weakly induced it, whereas the other four markedly induced it. Collectively, these findings demonstrate that ToBRFV evades Tm\u20102\n                    <jats:sup>2<\/jats:sup>\n                    \u2010mediated resistance by attenuating MP\u2013Tm\u20102\n                    <jats:sup>2<\/jats:sup>\n                    interaction strength, thereby avoiding Tm\u20102\n                    <jats:sup>2<\/jats:sup>\n                    self\u2010association and downstream immune activation.\n                  <\/jats:p>","DOI":"10.1111\/mpp.70243","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T07:34:57Z","timestamp":1773905697000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Tomato Brown Rugose Fruit Virus Evades Tm\u20102\n                    <sup>2<\/sup>\n                    \u2010Mediated Resistance by Avoiding the Induction of Tm\u20102\n                    <sup>2<\/sup>\n                    Self\u2010Association"],"prefix":"10.1111","volume":"27","author":[{"given":"Hua\u2010Yu","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Plant Pathology, College of Plant Protection Shandong Agricultural University  Tai'an Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Jie","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Plant Pathology, College of Plant Protection Shandong Agricultural University  Tai'an Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Xue","family":"Huan","sequence":"additional","affiliation":[{"name":"Department of Plant Pathology, College of Plant Protection Shandong Agricultural University  Tai'an Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu\u2010Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Plant Pathology, College of Plant Protection Shandong Agricultural University  Tai'an Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu\u2010Qi","family":"Mu","sequence":"additional","affiliation":[{"name":"Department of Plant Pathology, College of Plant Protection Shandong Agricultural University  Tai'an Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Meng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Plant Pathology, College of Plant Protection Shandong Agricultural University  Tai'an Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi\u2010Long","family":"Bao","sequence":"additional","affiliation":[{"name":"College of Horticulture Science and Engineering Shandong Agricultural University  Tai'an Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010Ping","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Plant Pathology, College of Plant Protection Shandong Agricultural University  Tai'an Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8253-0694","authenticated-orcid":false,"given":"Zhi\u2010Yong","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Plant Pathology, College of Plant Protection Shandong Agricultural University  Tai'an Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9838-0045","authenticated-orcid":false,"given":"Xiang\u2010Dong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Plant Pathology, College of Plant Protection Shandong Agricultural University  Tai'an Shandong China"},{"name":"Shandong Key Laboratory for Green Prevention and Control of Agricultural Pests, Institute of Plant Protection Shandong Academy of Agricultural Sciences  Ji'nan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.16.01512"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003659"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/nph.18183"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI-01-21-0023-R"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/mpp.13318"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/mpp.13182"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molp.2019.01.005"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05286"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf6395"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11262-022-01921-9"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1025434519282"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2015.01.014"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6750-8-91"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0170429"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/pbi.70138"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-00473-z"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42483-023-00162-4"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008475"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-025-3026-7"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.67.11.6432-6438.1993"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/nph.18457"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/mpp.13115"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2095-3119(20)63275-0"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/mpp.13017"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/mp\/sss153"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.112.209213"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.17.00180"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1099\/jgv.0.000496"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.04.028"}],"container-title":["Molecular Plant Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bsppjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/mpp.70243","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bsppjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/mpp.70243","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bsppjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/mpp.70243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T09:06:04Z","timestamp":1774602364000},"score":1,"resource":{"primary":{"URL":"https:\/\/bsppjournals.onlinelibrary.wiley.com\/doi\/10.1111\/mpp.70243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/mpp.70243"],"URL":"https:\/\/doi.org\/10.1111\/mpp.70243","archive":["Portico"],"relation":{},"ISSN":["1464-6722","1364-3703"],"issn-type":[{"value":"1464-6722","type":"print"},{"value":"1364-3703","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2026-01-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70243"}}