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Two MATH domain\u2010containing genes,\n                    <jats:italic>ParPMC1<\/jats:italic>\n                    and\n                    <jats:italic>ParPMC2<\/jats:italic>\n                    , have been identified in apricot as host susceptibility factors required for PPV infection, but their molecular function remains unclear. Here, we investigated ParPMC functions by identifying their interacting partners and assessing their contribution to viral replication and movement. Yeast two\u2010hybrid screening of PPV\u2010infected apricot tissues revealed 13 ParPMC interactors involved in defence and stress responses, primary metabolism, protein folding and gene expression. Among them, two eukaryotic elongation factor 1\u2010\u03b1 proteins (eEF1A; Pruar1 and Pruar9) were selected for further analysis. In planta assays showed that both ParPMC proteins colocalize with eEF1A at endoplasmic reticulum\u2010derived perinuclear structures associated with viral replication complexes; however, a specific physical interaction was detected only for ParPMC1, suggesting paralog specialisation. Phylogenetic analyses revealed independent diversification of\n                    <jats:italic>eEF1A<\/jats:italic>\n                    gene families in Rosaceae and Solanaceae. Despite the lack of strict orthology, silencing clade B\n                    <jats:italic>eEF1A<\/jats:italic>\n                    isoforms in\n                    <jats:italic>Nicotiana benthamiana<\/jats:italic>\n                    using a cucumber mosaic virus\u2010based virus\u2010induced gene silencing system strongly reduced PPV accumulation and systemic spread, highlighting a conserved proviral role. These results support a model in which ParPMC1 facilitates PPV infection by recruiting or stabilising eEF1A at viral replication sites, whereas ParPMC2 may contribute through alternative interactors. This study advances our understanding of\n                    <jats:italic>ParPMC<\/jats:italic>\n                    \u2010mediated PPV\u2010susceptibility in apricot and highlights host\u2013virus interactions with potential relevance for resistance strategies in\n                    <jats:italic>Prunus<\/jats:italic>\n                    and other potyvirus\u2010susceptible crops.\n                  <\/jats:p>","DOI":"10.1111\/mpp.70247","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T17:47:57Z","timestamp":1779385677000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeting\n                    <scp>ParPMC<\/scp>\n                    Susceptibility Hubs in\n                    <i>Prunus<\/i>\n                    :\n                    <scp>eEF1A<\/scp>\n                    as a Conserved Mediator of Plum Pox Virus Infection in\n                    <i>Nicotiana benthamiana<\/i>"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1519-3082","authenticated-orcid":false,"given":"\u00c1ngela","family":"Polo\u2010Oltra","sequence":"first","affiliation":[{"name":"Instituto Valenciano de Investigaciones Agrarias (IVIA) Centro de Citricultura y Producci\u00f3n Vegetal  Moncada Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8444-2217","authenticated-orcid":false,"given":"Alba","family":"Lloret","sequence":"additional","affiliation":[{"name":"Instituto Valenciano de Investigaciones Agrarias (IVIA) Centro de Citricultura y Producci\u00f3n Vegetal  Moncada Valencia Spain"},{"name":"Instituto de Biolog\u00eda Molecular y Celular de Plantas (IBMCP), Consejo Superior de Investigaciones Cient\u00edficas (CSIC) Universidad Polit\u00e9cnica de Valencia (UPV)  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3320-2827","authenticated-orcid":false,"given":"Jes\u00fas A.","family":"S\u00e1nchez\u2010Navarro","sequence":"additional","affiliation":[{"name":"Instituto de Biolog\u00eda Molecular y Celular de Plantas (IBMCP), Consejo Superior de Investigaciones Cient\u00edficas (CSIC) Universidad Polit\u00e9cnica de Valencia (UPV)  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1398-282X","authenticated-orcid":false,"given":"Gabino","family":"R\u00edos","sequence":"additional","affiliation":[{"name":"Instituto Valenciano de Investigaciones Agrarias (IVIA) Centro de Citricultura y Producci\u00f3n Vegetal  Moncada Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5316-8312","authenticated-orcid":false,"given":"Carlos","family":"Romero","sequence":"additional","affiliation":[{"name":"Instituto de Biolog\u00eda Molecular y Celular de Plantas (IBMCP), Consejo Superior de Investigaciones Cient\u00edficas (CSIC) Universidad Polit\u00e9cnica de Valencia (UPV)  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5497-4941","authenticated-orcid":false,"given":"Elena","family":"Zuriaga","sequence":"additional","affiliation":[{"name":"Instituto Valenciano de Investigaciones Agrarias (IVIA) Centro de Citricultura y Producci\u00f3n Vegetal  Moncada Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41438-019-0140-8"},{"key":"e_1_2_12_3_1","first-page":"49","article-title":"Plum Pox. 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