{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T04:19:04Z","timestamp":1789532344066,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002865","name":"Chongqing Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["CSTB2024NSCQ\u2010MSX1133"],"award-info":[{"award-number":["CSTB2024NSCQ\u2010MSX1133"]}],"id":[{"id":"10.13039\/501100002865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bsppjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Plant Pathology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Ubiquitin\u2010proteasome is a conserved mechanism that regulates cellular responses and disease resistance in plants. However, the regulatory role of ubiquitin\u2010proteasome in the pathogenicity of \u201c\n                    <jats:italic>Candidatus<\/jats:italic>\n                    Liberibacter asiaticus\u201d (\n                    <jats:italic>C<\/jats:italic>\n                    Las), the causal agent of citrus huanglongbing (HLB), one of the most serious citrus diseases, remains poorly defined. In this study, we demonstrated that CLIBASIA_04250 (SDE4250) suppresses 26S proteasome activity in citrus, leading to a reduction in salicylic acid (SA) levels and downregulation of SA\u2010responsive genes. Further investigation revealed that SDE4250 specifically targets the citrus 26S proteasome non\u2010ATPase regulatory subunit 4 homologue (CsRPN10) and enhances its degradation via the 26S proteasome pathway. Moreover, overexpression of\n                    <jats:italic>CsRPN10<\/jats:italic>\n                    inhibited\n                    <jats:italic>C<\/jats:italic>\n                    Las proliferation in citrus hairy roots, which was accompanied by a significant accumulation of SA content and upregulation of related defence genes. Collectively, our findings indicate that SDE4250 targets the citrus 26S proteasome to disrupt SA\u2010mediated citrus immunity.\n                  <\/jats:p>","DOI":"10.1111\/mpp.70264","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:29:06Z","timestamp":1777451346000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["\u2018\n                    <i>Candidatus<\/i>\n                    Liberibacter asiaticus\u2019 Effector\n                    <scp>SDE4250<\/scp>\n                    Targets Citrus Proteasome Protein\n                    <scp>RPN10<\/scp>\n                    to Inhibit Salicylic Acid\u2010Mediated Citrus Immunity"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5352-5081","authenticated-orcid":false,"given":"Yalin","family":"Mei","sequence":"first","affiliation":[{"name":"Integrative Science Center of Germplasm Creation in Western China (Chongqing) Science City Citrus Research Institute, Southwest University  Chongqing China"},{"name":"National Citrus Engineering Research Center, Citrus Research Institute Southwest University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Deng","sequence":"additional","affiliation":[{"name":"Integrative Science Center of Germplasm Creation in Western China (Chongqing) Science City Citrus Research Institute, Southwest University  Chongqing China"},{"name":"National Citrus Engineering Research Center, Citrus Research Institute Southwest University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaiyu","family":"Yang","sequence":"additional","affiliation":[{"name":"Integrative Science Center of Germplasm Creation in Western China (Chongqing) Science City Citrus Research Institute, Southwest University  Chongqing China"},{"name":"National Citrus Engineering Research Center, Citrus Research Institute Southwest University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiying","family":"Wang","sequence":"additional","affiliation":[{"name":"Integrative Science Center of Germplasm Creation in Western China (Chongqing) Science City Citrus Research Institute, Southwest University  Chongqing China"},{"name":"National Citrus Engineering Research Center, Citrus Research Institute Southwest University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Integrative Science Center of Germplasm Creation in Western China (Chongqing) Science City Citrus Research Institute, Southwest University  Chongqing China"},{"name":"National Citrus Engineering Research Center, Citrus Research Institute Southwest University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Integrative Science Center of Germplasm Creation in Western China (Chongqing) Science City Citrus Research Institute, Southwest University  Chongqing China"},{"name":"National Citrus Engineering Research Center, Citrus Research Institute Southwest University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingzhe","family":"Yuan","sequence":"additional","affiliation":[{"name":"Integrative Science Center of Germplasm Creation in Western China (Chongqing) Science City Citrus Research Institute, Southwest University  Chongqing China"},{"name":"National Citrus Engineering Research Center, Citrus Research Institute Southwest University  Chongqing 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jxb\/ery216"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010biochem\u2010062917\u2010011931"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.71.11.6473\u20106478.2005"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008780"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201004140\u20109"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.04.023"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jipb.12437"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/mpp.13296"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI\u201022\u20108\u20101011"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbi.2009.05.004"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010phyto\u2010073009\u2010114418"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1012542"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06926"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6430"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22169003"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21041414"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xplc.2023.100626"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.4c12314"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2022.06.006"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469\u20108137.2012.04266.x"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2022.997825"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/jxb\/erad176"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2023.2213040"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1099\/ijs.0.63677\u20100"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003427"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2688"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scienta.2023.112298"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201045521\u20107"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2020107257"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/mpp.70002"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adq7203"}],"container-title":["Molecular 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