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Due to the absence of highly resistant wheat varieties, chemical control remains the primary method for managing FHB. This study identified two homologous\n                    <jats:italic>SDHC<\/jats:italic>\n                    genes in\n                    <jats:italic>F.\u2009asiaticum<\/jats:italic>\n                    , namely\n                    <jats:italic>FaSDHC1<\/jats:italic>\n                    and\n                    <jats:italic>FaSDHC2<\/jats:italic>\n                    . Deletion of\n                    <jats:italic>FaSDHC2<\/jats:italic>\n                    impaired fungal sporulation, virulence and DON production, whereas the loss of\n                    <jats:italic>FaSDHC1<\/jats:italic>\n                    increased DON production. Both genes were found to regulate sensitivity to SDHI fungicides\u2014\u0394FaSDHC1 showed decreased sensitivity, while \u0394FaSDHC2 exhibited increased sensitivity. To explore the regulatory role of the SdhC subunit in SDHI fungicides sensitivity in\n                    <jats:italic>F.\u2009asiaticum<\/jats:italic>\n                    , this study obtained 11 boscalid\u2010resistant mutants from \u0394FaSDHC2 through chemical taming. Genetic analysis identified six mutation genotypes, including two previously reported in\n                    <jats:italic>Fusarium<\/jats:italic>\n                    species (FaSdhB\u2010H248Y and FaSdhD\u2010E166K) and four novel mutations in the\n                    <jats:italic>Fusarium<\/jats:italic>\n                    genus (FaSdhC1\u2010H144Y, FaSdhC1\u2010H144N, FaSdhD\u2010H122Y and FaSdhD\u2010D133N). The site\u2010directed mutation verification and sensitivity assays revealed that mutants harbouring FaSdhC1\u2010H144Y\/N, FaSdhD\u2010H122Y, FaSdhD\u2010D133N or FaSdhD\u2010E166K exhibited resistance to multiple SDHI fungicides (boscalid, fluopyram, pydiflumetofen, isopyrazam and benzovindiflupyr). In contrast, FaSdhB\u2010H248Y mutants remained sensitive to fluopyram while showing resistance to other SDHI fungicides. This study elucidates the important regulatory role of SdhC genetic differentiation to SDHI fungicide sensitivity in\n                    <jats:italic>F.\u2009asiaticum<\/jats:italic>\n                    . Furthermore, it confirms that specific variations within distinct subunits of the SDH complex endow\n                    <jats:italic>F.\u2009asiaticum<\/jats:italic>\n                    with resistance to SDHI fungicides. The findings advance understanding of SDHI fungicides resistance mechanisms and provide a basis for developing FaSdhC\u2010specific inhibitors and resistance management strategies.\n                  <\/jats:p>","DOI":"10.1111\/mpp.70269","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T05:53:32Z","timestamp":1778046812000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Genetic Differentiation in the\n                    <scp>S<\/scp>\n                    dh\n                    <scp>C<\/scp>\n                    Subunit Confers Intrinsic Resistance to\n                    <scp>SDHI<\/scp>\n                    Fungicides in\n                    <i>Fusarium asiaticum<\/i>"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3414-7059","authenticated-orcid":false,"given":"Jichang","family":"Song","sequence":"first","affiliation":[{"name":"State Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection Nanjing Agricultural University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiakai","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection Nanjing Agricultural University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection Nanjing Agricultural University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinkai","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection Nanjing Agricultural University  Nanjing Jiangsu 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