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Here, we provide evidence that the cucumber mosaic virus (CMV) coat protein (CP) interacts with the host kinase CDPK7\u2010like in\n                    <jats:italic>Nicotiana benthamiana<\/jats:italic>\n                    . In an overexpression system, this interaction facilitates liquid\u2013liquid phase separation (LLPS), forming condensate\u2010like structures that could influence host immune\u2010related signalling. Strikingly, plants overexpressing the\n                    <jats:italic>CDPK7\u2010like<\/jats:italic>\n                    gene exhibited significantly enhanced resistance against diverse viruses, including potato virus Y and pepper mild mottle virus, yet displayed heightened susceptibility to CMV, suggesting virus\u2010specific hijacking. Notably, a coumarin\u2010based small\u2010molecule LLPS modulator\n                    <jats:bold>D3<\/jats:bold>\n                    is developed, which selectively targets the critical Thr52 residue within CMV CP to rescue CDPK7\u2010like from LLPS initiation. Stands in contrast to the commercial drug ribavirin (EC\n                    <jats:sub>50<\/jats:sub>\n                    \u2009=\u2009195\u2009\u03bcg\/mL),\n                    <jats:bold>D3<\/jats:bold>\n                    shows better inactivating property against CMV (EC\n                    <jats:sub>50<\/jats:sub>\n                    \u2009=\u200970.8\u2009\u03bcg\/mL). This study reveals a mechanism by which CMV manipulates a host factor through phase separation and contributes a promising lead compound\n                    <jats:bold>D3<\/jats:bold>\n                    for strategies aimed at enabling plants to win pathogen battles.\n                  <\/jats:p>","DOI":"10.1111\/mpp.70270","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T08:37:37Z","timestamp":1779093457000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cucumber Mosaic Virus Coat Protein Sequesters Host\n                    <scp>CDPK7<\/scp>\n                    \u2010Like Into Phase\u2010Separated Condensates to Promote Viral Infection"],"prefix":"10.1111","volume":"27","author":[{"given":"Lei","family":"Zhao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Green Pesticide Guizhou University  Guiyang 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