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Plant resistance to pathogens relies on a sophisticated innate immune system, which is often targeted by pathogen\u2010derived effectors.\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>P. infestans<\/jats:italic>\n                    <\/jats:styled-content>\n                    secretes numerous RXLR effectors to suppress host immunity. In this study, we show that the\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>P. infestans<\/jats:italic>\n                    <\/jats:styled-content>\n                    core effector Pi05910 functions as a virulence factor and targets the host scaffold protein Receptor for Activated C Kinase 1 (RACK1), which is identified to positively regulate potato resistance to late blight. Functional analyses showed that\n                    <jats:italic>StRACK1<\/jats:italic>\n                    \u2010silencing in potato, and tobacco rattle virus (TRV)\u2010based virus\u2010induced\n                    <jats:italic>NbRACK1<\/jats:italic>\n                    \u2010silencing in\n                    <jats:italic>Nicotiana benthamiana<\/jats:italic>\n                    , consistently increased host susceptibility to\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>P. infestans<\/jats:italic>\n                    <\/jats:styled-content>\n                    colonisation, whereas transient expression of\n                    <jats:italic>NbRACK1<\/jats:italic>\n                    in\n                    <jats:italic>N. benthamiana<\/jats:italic>\n                    or stable overexpression of\n                    <jats:italic>StRACK1<\/jats:italic>\n                    in potato enhanced late blight resistance. Pi05910 physically interacts with RACK1 and promotes its destabilisation via the host 26S proteasome pathway. The destabilisation of RACK1 led to the inhibition of PAMP elicitor INF1\u2010triggered plant immune responses, including reactive oxygen species burst and expression of defence\u2010related genes such as\n                    <jats:italic>StWRKY7<\/jats:italic>\n                    and\n                    <jats:italic>StWRKY8<\/jats:italic>\n                    , and suppression of potato and\n                    <jats:italic>N. benthamiana<\/jats:italic>\n                    growth and global protein translation. Our findings reveal a strategy whereby a pathogen effector sabotages a key potato immune scaffold StRACK1 to promote plant susceptibility to\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>P. infestans<\/jats:italic>\n                    <\/jats:styled-content>\n                    infection, providing new insight into mechanisms of effector\u2010triggered plant susceptibility.\n                  <\/jats:p>","DOI":"10.1111\/mpp.70311","type":"journal-article","created":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T06:22:32Z","timestamp":1783146152000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Late Blight Effector Pi05910 Suppresses Plant Immunity by Promoting Destabilisation of Host Scaffold Protein\n                    <scp>RACK1<\/scp>"],"prefix":"10.1111","volume":"27","author":[{"given":"Xiong","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Crop Stress Resistance and High\u2010Efficiency Production and College of Agronomy Northwest A&amp;F University  Yangling Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yisa","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Crop Stress Resistance and High\u2010Efficiency Production and College of Agronomy Northwest A&amp;F University  Yangling Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Crop Stress Resistance and High\u2010Efficiency Production and College of Agronomy Northwest A&amp;F University  Yangling Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiran","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Crop Stress Resistance and High\u2010Efficiency Production and College of Agronomy Northwest A&amp;F University  Yangling Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwen","family":"Ding","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Crop Stress Resistance and High\u2010Efficiency Production and College of Agronomy Northwest A&amp;F University  Yangling Shaanxi China"},{"name":"College of Plant Protection Northwest A&amp;F University  Yangling Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Altyn","family":"Shayakhmetova","sequence":"additional","affiliation":[{"name":"Department of Agronomy and Forestry M. Kozybayev North Kazakhstan State University  Petropavlovsk Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuling","family":"Meng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Crop Stress Resistance and High\u2010Efficiency Production and College of Agronomy Northwest A&amp;F University  Yangling Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7286-4041","authenticated-orcid":false,"given":"Weixing","family":"Shan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Crop Stress Resistance and High\u2010Efficiency Production and College of Agronomy Northwest A&amp;F University  Yangling Shaanxi China"},{"name":"Shenzhen Research Institute Northwest A&amp;F University  Shenzhen 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