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However, the mechanistic basis underlying their regulation of plant immunity to different pathogens is still poorly understood. Here, we showed that the small GTPase Ras homologous 1 (RHO1) responded differently to infection by distinct pathogens. Overexpression of\n                    <jats:italic>RHO1<\/jats:italic>\n                    increased the plant susceptibility to chilli veinal mottle virus (ChiVMV) and necrotrophic\n                    <jats:italic>Botrytis cinerea<\/jats:italic>\n                    infections but enhanced plant resistance to the biotrophic bacterium\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Pseudomonas syringae<\/jats:italic>\n                    <\/jats:styled-content>\n                    . Further exploration revealed that there existed a direct interaction between RHO1 and tonoplast intrinsic protein 1;1 (TIP1;1), an aquaporin involved in water movement and the transport of hydrogen peroxide (H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ) between vacuoles and cytoplasm. Under pathogen infection, the interaction between RHO1 and TIP1;1 could affect the distribution of reactive oxygen species (ROS) in the cytoplasm and vacuoles, promote the accumulation of ROS in the cytoplasm, leading to different responses of plant cells to pathogens with different lifestyles. Furthermore, the expression level of\n                    <jats:italic>TIP1;1<\/jats:italic>\n                    was altered under infection by different pathogens. Our results demonstrate a mechanism by which the small GTPase RHO1 regulates ROS compartmentalization to affect the plant response to different pathogen infections, indicating the diversity of responses of a plant gene to different biotic factors.\n                  <\/jats:p>","DOI":"10.1111\/mpp.70333","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T05:21:16Z","timestamp":1787980876000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Small\n                    <scp>GTPase RHO1<\/scp>\n                    Regulates\n                    <scp>ROS<\/scp>\n                    Homeostasis and Differentially Responds to Pathogens Infection via Interaction With Aquaporin\n                    <scp>TIP1<\/scp>\n                    ;1 in\n                    <i>Nicotiana<\/i>"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1998-8594","authenticated-orcid":false,"given":"Bowen","family":"Yuan","sequence":"first","affiliation":[{"name":"Key Laboratory of Bio\u2010Resource and Eco\u2010Environment of Ministry of Education, College of Life Sciences Sichuan University  Chengdu Sichuan China"},{"name":"Southwest Bio\u2010Resources R&amp;D Key Laboratory of Sichuan Province Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenglong","family":"Ji","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bio\u2010Resource and Eco\u2010Environment of Ministry of Education, College of Life Sciences Sichuan University  Chengdu Sichuan China"},{"name":"Southwest Bio\u2010Resources R&amp;D Key Laboratory of Sichuan Province Sichuan University  Chengdu Sichuan 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Province Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Plant Protection Sichuan Academy of Agricultural Sciences  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0989-5627","authenticated-orcid":false,"given":"Jianmin","family":"Zeng","sequence":"additional","affiliation":[{"name":"Yunnan Academy of Tobacco Agricultural Sciences  Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2582-4041","authenticated-orcid":false,"given":"Cheng","family":"Yuan","sequence":"additional","affiliation":[{"name":"Yunnan Academy of Tobacco Agricultural Sciences  Kunming Yunnan 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