{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T06:41:01Z","timestamp":1792478461107,"version":"4.5.0"},"reference-count":56,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32570212"],"award-info":[{"award-number":["32570212"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20480"],"award-info":[{"award-number":["U22A20480"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005270","name":"Fujian Provincial Department of Science and Technology","doi-asserted-by":"publisher","award":["2023J01440"],"award-info":[{"award-number":["2023J01440"]}],"id":[{"id":"10.13039\/501100005270","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005270","name":"Fujian Provincial Department of Science and Technology","doi-asserted-by":"publisher","award":["2022J01128"],"award-info":[{"award-number":["2022J01128"]}],"id":[{"id":"10.13039\/501100005270","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bsppjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Plant Pathology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Rice foot rot, caused by\n Dickeya oryzae<\/jats:italic>\n , is a destructive bacterial disease. The Vfm quorum\u2010sensing (QS) system is a key virulence regulator of this pathogen. However, the mechanisms by which it perceives and integrates upstream environmental signals for precise transcriptional control are poorly understood. Here, we identify a cascade regulatory network involving the MarR\u2010family transcription factors OhrR and EmrR. Deletion of\n ohrR<\/jats:italic>\n in\n \n D.\u2009oryzae<\/jats:italic>\n <\/jats:styled-content>\n EC1 significantly reduced the Vfm signalling activity, diminished the production of virulence factors including phytotoxin zeamines and plant cell wall\u2010degrading enzymes, and attenuated its pathogenicity. Molecular analyses revealed that OhrR directly bound to the key promoters in the\n vfm<\/jats:italic>\n cluster (P\n \n vfmA<\/jats:italic>\n <\/jats:sub>\n , P\n \n vfmK<\/jats:italic>\n <\/jats:sub>\n , P\n \n vfmE<\/jats:italic>\n <\/jats:sub>\n and P\n \n vfmF<\/jats:italic>\n <\/jats:sub>\n ) and activated their transcription. Intriguingly, OhrR also directly activated the expression of\n emrR<\/jats:italic>\n , which encodes another MarR\u2010family transcriptional regulator. In contrast to the activator role of OhrR, EmrR acted as a feedback inhibitor, directly bound to the same\n vfm<\/jats:italic>\n promoter regions but repressed their transcription. OhrR\u2013EmrR thus acts as a two\u2010tiered \u2018activation\u2013inhibition\u2019 regulatory circuit in modulation of the Vfm QS system, in which OhrR functions as a master switch for environmental signal response and initiation of the Vfm system, whereas EmrR acts as a precise brake to prevent overexpression of virulence determinants. The findings from this study unveil the fascinating interaction between OhrR\u2013EmrR and the Vfm QS system, and depict a novel mechanism for precise virulence control in\n \n D.\u2009oryzae<\/jats:italic>\n <\/jats:styled-content>\n via complex, dynamic transcriptional reprogramming.\n <\/jats:p>","DOI":"10.1111\/mpp.70354","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T06:10:23Z","timestamp":1792476623000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Hierarchical\n OhrR<\/scp>\n \u2013\n EmrR<\/scp>\n Regulatory Circuit Fine\u2010Tunes the Vfm Quorum\u2010 Sensing System and Virulence in\n Dickeya oryzae<\/i>"],"prefix":"10.1111","volume":"27","author":[{"given":"Wenqi","family":"Huang","sequence":"first","affiliation":[{"name":"College of Plant Protection Fujian Agriculture and Forestry University Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwei","family":"Meng","sequence":"additional","affiliation":[{"name":"College of Plant Protection Fujian Agriculture and Forestry University Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongge","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Plant Protection Fujian Agriculture and Forestry University Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihan","family":"Gu","sequence":"additional","affiliation":[{"name":"Integrative Microbiology Research Centre South China Agricultural University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1233-6762","authenticated-orcid":false,"given":"Ming","family":"Hu","sequence":"additional","affiliation":[{"name":"Integrative Microbiology Research Centre South China Agricultural University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhuo","sequence":"additional","affiliation":[{"name":"College of Plant Protection Fujian Agriculture and Forestry University Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4298-7988","authenticated-orcid":false,"given":"Lianhui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Integrative Microbiology Research Centre South China Agricultural University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4902-3716","authenticated-orcid":false,"given":"Mingfa","family":"Lv","sequence":"additional","affiliation":[{"name":"College of Plant Protection Fujian Agriculture and Forestry University Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1126\/science.1171647","article-title":"Innate Immunity in Plants: An Arms Race Between Pattern Recognition Receptors in Plants and Effectors in Microbial Pathogens","volume":"324","author":"Boller T.","year":"2009","journal-title":"Science"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1128\/aem.61.5.1959-1967.1995","article-title":"Inactivation of rsmA Leads to Overproduction of Extracellular Pectinases, Cellulases, and Proteases in \n Erwinia carotovora\n subsp. carotovora in the Absence of the Starvation\/Cell Density\u2010Sensing Signal, N\u2010(3\u2010Oxohexanoyl)\u2010L\u2010Homoserine Lactone","volume":"61","author":"Chatterjee A.","year":"1995","journal-title":"Applied and Environmental 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