{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T03:26:17Z","timestamp":1783826777162,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,12,21]],"date-time":"2014-12-21T00:00:00Z","timestamp":1419120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministero dell'Istruzione, dell'Universit\u00e0 e della Ricerca (PRIN 2010)"}],"content-domain":{"domain":["resjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medical Vet Entomology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"Abstract<\/jats:title>\n \n ATP<\/jats:styled-content>\n \u2010binding cassette (\n ABC<\/jats:styled-content>\n ) transporters have been shown to be involved in pesticide detoxification in arthropod vectors and are thought to contribute to the development of drug resistance. Little is currently known about the role they play in ticks, which are among the more important vectors of human and animal pathogens. Here, the role of\n ABC<\/jats:styled-content>\n transporters in the transport of fipronil and ivermectin acaricides in the tick\n \n R<\/jats:styled-content>\n hipicephalus sanguineus\n <\/jats:italic>\n (\n I<\/jats:styled-content>\n xodida:\n I<\/jats:styled-content>\n xodidae) was investigated. Larvae were treated with acaricide alone and acaricide in combination with a sub\u2010lethal dose of the\n ABC<\/jats:styled-content>\n transporter inhibitor cyclosporine\n A<\/jats:styled-content>\n . The\n \n LC\n 50<\/jats:sub>\n <\/jats:styled-content>\n doses and 95% confidence intervals (\n CI<\/jats:styled-content>\n s) estimated by mortality data using probit analysis were 67.930\u2009p.p.m. (95%\n CI<\/jats:styled-content>\n 53.780\u201390.861) for fipronil and 3741\u2009p.p.m. (95%\n CI<\/jats:styled-content>\n 2857\u20134647) for ivermectin. The pre\u2010exposure of larvae to a sub\u2010lethal dose of cyclosporine\n A<\/jats:styled-content>\n reduced the\n \n LC\n 50<\/jats:sub>\n <\/jats:styled-content>\n dose of fipronil to 4.808\u2009p.p.m. (95%\n CI<\/jats:styled-content>\n 0.715\u20139.527) and that of ivermectin to 167\u2009p.p.m. (95%\n CI<\/jats:styled-content>\n 15\u2013449), which increased toxicity by about 14\u2010 and 22\u2010fold, respectively. The comparison of mortality data for each separate acaricide concentration showed the synergic effect of cyclosporine\n A<\/jats:styled-content>\n to be reduced at higher concentrations of acaricide. These results show for the first time a strong association between\n ABC<\/jats:styled-content>\n transporters and acaricide detoxification in\n \n R<\/jats:styled-content>\n .sanguineus s.l.\n <\/jats:italic>\n <\/jats:p>","DOI":"10.1111\/mve.12093","type":"journal-article","created":{"date-parts":[[2014,12,21]],"date-time":"2014-12-21T23:40:50Z","timestamp":1419205250000},"page":"88-93","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Potential role of\n ATP<\/scp>\n \u2010binding cassette transporters against acaricides in the brown dog tick\n \n R<\/scp>\n hipicephalus sanguineus sensu lato\n <\/i>"],"prefix":"10.1111","volume":"29","author":[{"given":"C.","family":"CAFARCHIA","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine University \u2018Aldo Moro\u2019 of Bari Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"PORRETTA","sequence":"additional","affiliation":[{"name":"Department of Environmental Biology University of Rome \u2018La Sapienza\u2019 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"MASTRANTONIO","sequence":"additional","affiliation":[{"name":"Department of Environmental Biology University of Rome \u2018La Sapienza\u2019 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"EPIS","sequence":"additional","affiliation":[{"name":"Department of Veterinary Science and Public Health University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"SASSERA","sequence":"additional","affiliation":[{"name":"Department of Biology and Biotechnology University of Pavia Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"IATTA","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine University \u2018Aldo Moro\u2019 of Bari Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"IMMEDIATO","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine University \u2018Aldo Moro\u2019 of Bari Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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