{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:37:17Z","timestamp":1792107437907,"version":"4.4.0"},"reference-count":64,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,10,18]],"date-time":"2016-10-18T00:00:00Z","timestamp":1476748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["resjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medical Vet Entomology"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Little is known about how the virulence of a human pathogen varies in the environment it shares with its vector. This study focused on whether the virulence of\n                    <jats:italic>Trypanosoma cruzi<\/jats:italic>\n                    (Trypanosomatida: Trypanosomatidae), the causal agent of Chagas' disease, is related to altitude. Accordingly,\n                    <jats:italic>Triatoma dimidiata<\/jats:italic>\n                    (Hemiptera: Reduviidae) specimens were collected at three different altitudes (300, 700 and 1400 m a.s.l.) in Chiapas, Mexico. The parasite was then isolated to infect uninfected\n                    <jats:italic>T. dimidiata<\/jats:italic>\n                    from the same altitudes, as well as female CD\u20101 mice. The response variables were phenoloxidase (PO) activity, a key insect immune response, parasitaemia in mice, and amastigote numbers in the heart, oesophagus, gastrocnemius and brain of the rodents. The highest levels of PO activity, parasitaemia and amastigotes were found for\n                    <jats:italic>Tryp. cruzi<\/jats:italic>\n                    isolates sourced from 700 m a.s.l., particularly in the mouse brain. A polymerase chain reaction\u2010based analysis indicated that all\n                    <jats:italic>Tryp. cruzi<\/jats:italic>\n                    isolates belonged to a\n                    <jats:italic>Tryp. cruzi<\/jats:italic>\n                    I lineage. Thus,\n                    <jats:italic>Tryp. cruzi<\/jats:italic>\n                    from 700 m a.s.l. may be more dangerous than sources at other altitudes. At this altitude,\n                    <jats:italic>T. dimidiata<\/jats:italic>\n                    is more common, apparently because the conditions are more beneficial to its development. Control strategies should focus activity at altitudes around 700 m a.s.l., at least in relation to the region of the present study sites.\n                  <\/jats:p>","DOI":"10.1111\/mve.12198","type":"journal-article","created":{"date-parts":[[2016,10,18]],"date-time":"2016-10-18T04:33:46Z","timestamp":1476765226000},"page":"63-71","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Relationships between altitude, triatomine (\n                    <i>Triatoma dimidiata<\/i>\n                    ) immune response and virulence of\n                    <i>Trypanosoma cruzi<\/i>\n                    , the causal agent of Chagas' disease"],"prefix":"10.1111","volume":"31","author":[{"given":"J. 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