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Previous studies focused only on the effect of systemic control on vector abundance at small spatial scales. None were conducted at a spatial scale relevant for vector control and none on the effect of systemic control on pathogen transmission rates. We tested the application of systemic control, using Fipronil\u2010impregnated rodent baits, in reducing\n                    <jats:italic>Leishmania major<\/jats:italic>\n                    (\n                    <jats:italic>Kinetoplastida: Trypanosomatidae<\/jats:italic>\n                    ; Yakimoff &amp; Schokhor, 1914) infection levels within the vector,\n                    <jats:italic>Phlebotomus papatasi<\/jats:italic>\n                    (Diptera: Psychodidae; Scopoli, 1786) population, at the town\u2010scale. We provided Fipronil\u2010impregnated food\u2010baits to all\n                    <jats:italic>Psammomys obesus<\/jats:italic>\n                    (Mammalia:Muridae; Cretzschmar, 1828)\n                    <jats:italic>, the main L. major<\/jats:italic>\n                    reservoir, burrows along the southern perimeter of the town of Yeruham, Israel, and compared sand fly abundance and infection levels with a non\u2010treated control area. We found a significant and substantial treatment effect on\n                    <jats:italic>L. major<\/jats:italic>\n                    infection levels in the female sand fly population. Sand fly abundance was not affected. Our results demonstrate, for the first time, the potential of systemic control in reducing pathogen transmission rates at a large, epidemiologically relevant, spatial scale.\n                  <\/jats:p>","DOI":"10.1111\/mve.12608","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T05:05:48Z","timestamp":1661317548000},"page":"4-13","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Large scale systemic control short\u2010circuits pathogen transmission by interrupting the sand rat (\n                    <i>Psammomys obesus<\/i>\n                    )\u2010to\u2010sand fly (\n                    <i>Phlebotomus papatasi<\/i>\n                    )\n                    <i>Leishmania major<\/i>\n                    transmission cycle"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8510-3089","authenticated-orcid":false,"given":"Ido","family":"Tsurim","sequence":"first","affiliation":[{"name":"Department of Life Sciences Achva Academic College  Israel"},{"name":"Department of Life Sciences Ben\u2010Gurion University of the Negev  Beer\u2010Sheva Israel"},{"name":"Gaza Envelope Research and Development Center  Netivot Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gideon","family":"Wasserberg","sequence":"additional","affiliation":[{"name":"Biology Department University of North Carolina at Greensboro  Greensboro North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alon","family":"Warburg","sequence":"additional","affiliation":[{"name":"The Kuvin Center for the Study of Infectious &amp; Tropical Diseases, Department of Microbiology and Molecular Genetics, The Institute of Medical Research, Israel\u2010Canada, The Faculty of Medicine The Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Abbasi","sequence":"additional","affiliation":[{"name":"The Kuvin Center for the Study of Infectious &amp; Tropical Diseases, Department of Microbiology and Molecular Genetics, The Institute of Medical Research, Israel\u2010Canada, The Faculty of Medicine The Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gil","family":"Ben Natan","sequence":"additional","affiliation":[{"name":"Department of Life Sciences Ben\u2010Gurion University of the Negev  Beer\u2010Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zvika","family":"Abramsky","sequence":"additional","affiliation":[{"name":"Department of Life Sciences Ben\u2010Gurion University of the Negev  Beer\u2010Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-13-153"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2915.2000.00237.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2009.02371.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2915.2003.00420.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-011-1276-0"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0738-081X(96)00041-7"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268802007148"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365548.2014.977342"},{"key":"e_1_2_10_10_1","unstructured":"Berger R.(2009)Determining the environmental risk factors for cutaneous Leishmaniasis (CL) in the Negev and possibilities for disease control. 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