{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T17:48:06Z","timestamp":1784310486883,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T00:00:00Z","timestamp":1668470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["IRIS ID:2020\u20100690"],"award-info":[{"award-number":["IRIS ID:2020\u20100690"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["resjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medical Vet Entomology"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Louse\u2010borne relapsing fever (LBRF) with high untreated mortality caused by spirochete\n                    <jats:italic>Borrelia recurrentis<\/jats:italic>\n                    is predominantly endemic to Sub\u2010Saharan Africa and has re\u2010emerged in parts of Eastern Europe, Asia and Latin America due to population migrations. Despite subtractive evolution of lice\u2010borne pathogenic\n                    <jats:italic>Borrelia<\/jats:italic>\n                    spp. from tick\u2010borne species, there has been no comprehensive report on conservation of protein targets across tick and lice\u2010borne pathogenic\n                    <jats:italic>Borrelia<\/jats:italic>\n                    nor exploration of phytocompounds that are toxic to tick against lice. From the 19 available whole genomes including\n                    <jats:italic>B. recurrentis<\/jats:italic>\n                    ,\n                    <jats:italic>B. burgdorferi<\/jats:italic>\n                    ,\n                    <jats:italic>B. hermsii<\/jats:italic>\n                    ,\n                    <jats:italic>B. parkeri<\/jats:italic>\n                    and\n                    <jats:italic>B. miyamotoi<\/jats:italic>\n                    , conservation of seven drug targets (&gt;80% domain identity) viz. 30\u2009S ribosomal subunit proteins (RSP) S3, S7, S8, S14, S19, penicillin\u2010binding protein\u20102 and 50\u2009S RSP L16 were deciphered through multiple sequence alignments. Twelve phytocompounds (hydroxy\u2010tyrosol, baicalein, cis\u20102\u2010decanoic acid, morin, oenin, rosemarinic acid, kaempferol, piceatannol, rottlerin, luteolin, fisetin and monolaurin) previously explored against Lyme disease spirochete\n                    <jats:italic>B. burgdorferi<\/jats:italic>\n                    when targeted against LBRF\u2010causing\n                    <jats:italic>B. recurrentis<\/jats:italic>\n                    protein targets revealed high multi\u2010target affinity (2%\u201320% higher than conventional antibiotics) through molecular docking. However, based on high binding affinity against all target proteins, stable coarse\u2010grained dynamics (fluctuations &lt;1\u00a0\u00c5) and safe pharmacological profile, luteolin was prioritized. The study encourages experimental evaluation of the potent phytocompounds and similar protocols for investigating other emerging vector\u2010borne diseases.\n                  <\/jats:p>","DOI":"10.1111\/mve.12623","type":"journal-article","created":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T05:26:05Z","timestamp":1668489965000},"page":"213-218","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Bioactive phytocompounds against specific target proteins of\n                    <i>Borrelia recurrentis<\/i>\n                    responsible for louse\u2010borne relapsing fever: Genomics and structural bioinformatics evidence"],"prefix":"10.1111","volume":"37","author":[{"given":"Soumya","family":"Basu","sequence":"first","affiliation":[{"name":"Medical and Biological Computing Laboratory School of Biosciences and Technology (SBST), Vellore Institute of Technology (VIT)  Vellore India"},{"name":"Department of Biotechnology, School of Biosciences and Technology (SBST), Vellore Institute of Technology (VIT)  Vellore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reetika","family":"Debroy","sequence":"additional","affiliation":[{"name":"Medical and Biological Computing Laboratory School of Biosciences and Technology (SBST), Vellore Institute of Technology (VIT)  Vellore India"},{"name":"Department of Bio Sciences, School of Biosciences and Technology (SBST), Vellore Institute of Technology (VIT)  Vellore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hithesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Bio Sciences, School of Biosciences and Technology (SBST), Vellore Institute of Technology (VIT)  Vellore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harpreet","family":"Singh","sequence":"additional","affiliation":[{"name":"Division of Biomedical Informatics Indian Council of Medical Research (ICMR)  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudha","family":"Ramaiah","sequence":"additional","affiliation":[{"name":"Medical and Biological Computing Laboratory School of Biosciences and Technology (SBST), Vellore Institute of Technology (VIT)  Vellore India"},{"name":"Department of Bio Sciences, School of Biosciences and Technology (SBST), Vellore Institute of Technology (VIT)  Vellore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2216-7488","authenticated-orcid":false,"given":"Anand","family":"Anbarasu","sequence":"additional","affiliation":[{"name":"Medical and Biological Computing Laboratory School of Biosciences and Technology (SBST), Vellore Institute of Technology (VIT)  Vellore India"},{"name":"Department of Biotechnology, School of Biosciences and Technology (SBST), Vellore Institute of Technology (VIT)  Vellore 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