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Years of extensive use of the readily available acaricides have resulted in widespread resistance development in these ticks, as well as negative environmental consequences. Benzyl alcohol (BA) has been frequently used to treat pediculosis and scabies, and it may be an effective alternative to commonly used acaricides. The main aim of the present study was to evaluate the acaricide activity of BA and its combination with the regularly used chemical acaricides against\n                    <jats:italic>R. annulatus<\/jats:italic>\n                    and\n                    <jats:italic>R. sanguineus<\/jats:italic>\n                    . Different concentrations of BA alone and in combination with deltamethrin, cypermethrin and chlorpyrifos were tested in vitro against adult and larvae of both tick species. The results showed that BA is toxic to\n                    <jats:italic>R. annulatus<\/jats:italic>\n                    and\n                    <jats:italic>R. sanguineus<\/jats:italic>\n                    larvae, with 100% larval mortality at concentrations of \u226550\u2009mL\/L, and LC\n                    <jats:sub>50<\/jats:sub>\n                    and LC\n                    <jats:sub>90<\/jats:sub>\n                    attained the concentrations of 19.8 and 33.8\u2009mL\/L for\n                    <jats:italic>R. annulatus<\/jats:italic>\n                    and 18.8 and 31.8\u2009mL\/L for\n                    <jats:italic>R. sanguineus<\/jats:italic>\n                    , respectively. Furthermore, BA in combination with deltamethrin, cypermethrin and chlorpyrifos exhibited synergistic factors of 2.48, 1.26 and 1.68 against\n                    <jats:italic>R. annulatus<\/jats:italic>\n                    larvae and 1.64, 11.1 and 1.14 against\n                    <jats:italic>R. sanguineus<\/jats:italic>\n                    larvae for deltamethrin + BA, cypermethrin + BA and chlorpyrifos + BA, respectively. BA induced 100% mortality in adult\n                    <jats:italic>R. annulatus<\/jats:italic>\n                    at concentrations of \u2265250\u2009mL\/L with LC\n                    <jats:sub>50<\/jats:sub>\n                    and LC\n                    <jats:sub>90<\/jats:sub>\n                    reached the concentrations of 111 and 154\u2009mL\/L, respectively. Additionally, BA had ovicidal activity causing complete inhibition of larval hatching at 100\u2009mL\/L. The combination of BA with deltamethrin and cypermethrin increased acetylcholinesterase inhibition, whereas the combination of BA with chlorpyrifos decreased glutathione (GSH) activity and malondialdehyde levels. In the field application, the combination of BA 50\u2009mL\/L and deltamethrin (DBA) resulted in a significant reduction in the percentage of ticks by 30.9% 28\u2009days post\u2010treatment when compared with groups treated with deltamethrin alone. In conclusion, BA causes mortality in laboratory and field studies alone and in combination with cypermethrin or deltamethrin. BA can be used for control of ticks of different life stages, that is, eggs and larvae, through application to the ground.\n                  <\/jats:p>","DOI":"10.1111\/mve.12698","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T23:45:53Z","timestamp":1697067953000},"page":"1-12","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["An investigation of the acaricidal activity of benzyl alcohol on\n                    <i>Rhipicephalus annulatus<\/i>\n                    and\n                    <i>Rhipicephalus sanguineus<\/i>\n                    and its synergistic or antagonistic interaction with commonly used acaricides"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1403-2527","authenticated-orcid":false,"given":"Shawky M.","family":"Aboelhadid","sequence":"first","affiliation":[{"name":"Parasitology Department, Faculty of Veterinary Medicine Beni\u2010Suef University  Beni Suef Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samar M.","family":"Ibrahium","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Animal Health Research Institute  Fayoum Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdel\u2010Azeem S.","family":"Abdel\u2010Baki","sequence":"additional","affiliation":[{"name":"Zoology Department, Faculty of Science Beni\u2010Suef University  Beni Suef Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khaled M.","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Animal Health Research Institute  Beni Suef Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waleed M.","family":"Arafa","sequence":"additional","affiliation":[{"name":"Parasitology Department, Faculty of Veterinary Medicine Beni\u2010Suef University  Beni Suef Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heba M.","family":"Aboud","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy Beni\u2010Suef University  Beni Suef Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Mohy","sequence":"additional","affiliation":[{"name":"Beni\u2010Suef Veterinary Clinic  Beni Suef Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saleh","family":"Al\u2010Quraishy","sequence":"additional","affiliation":[{"name":"Zoology Department, College of Science King Saud University  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed O.","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Medicine Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noha H.","family":"Abdelgelil","sequence":"additional","affiliation":[{"name":"Parasitology Department, Faculty of Medicine Minia University  Minia Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahar M.","family":"Gadelhaq","sequence":"additional","affiliation":[{"name":"Parasitology Department, Faculty of Veterinary Medicine Minia University  Minia Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0260172"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vprsr.2018.06.008"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10493-021-00627-1"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2011.12.002"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2021.109346"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ttbdis.2020.101488"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-736X2015000500012"},{"key":"e_1_2_9_9_1","unstructured":"Aronson J. 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