{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T04:10:44Z","timestamp":1770523844725,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["104926\/Z\/14\/Z"],"award-info":[{"award-number":["104926\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["resjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medical Vet Entomology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Mass ivermectin (IVM) treatment of livestock (MITL) is under consideration as a malaria control tool as IVM\u2010treated livestock are lethal to blood\u2010feeding\n                    <jats:italic>Anopheles<\/jats:italic>\n                    mosquitoes. MITL is routinely used as a prophylaxis in livestock to reduce the burden and transmission of helminth infections. Recently, there has been a shift in the veterinary IVM market in Southeast Asia wherein nearly all standard IVM formulations are now co\u2010formulated with clorsulon (CLO). CLO is used to treat the trematode liver fluke,\n                    <jats:italic>Fasciola hepatica.<\/jats:italic>\n                    Thus, the co\u2010administration of IVM and CLO simultaneously targets multiple livestock infections. Additionally,\n                    <jats:italic>F.\u2009hepatica<\/jats:italic>\n                    frequently afflicts human populations in endemic areas, making control of\n                    <jats:italic>F.\u2009hepatica<\/jats:italic>\n                    in livestock beneficial for One Health. CLO interrupts glycolysis in\n                    <jats:italic>F.\u2009hepatica<\/jats:italic>\n                    , but its potential effect against\n                    <jats:italic>Anopheles<\/jats:italic>\n                    mosquitoes has never been evaluated.\n                    <jats:italic>Anopheles dirus<\/jats:italic>\n                    mosquitoes were blood\u2010fed CLO across a range of concentrations (1\u201310,000\u2009nM; 0.38\u20133807\u2009ng\/mL), and mosquito survival was monitored for 10\u2009days. Co\u2010feeding experiments were also performed with\n                    <jats:italic>An.\u2009dirus<\/jats:italic>\n                    blood\u2010fed on IVM at two concentrations (4 and 6\u2009ng\/mL) without and with CLO corresponding to peak concentration in cattle (\n                    <jats:italic>C<\/jats:italic>\n                    <jats:sub>max<\/jats:sub>\n                    ) (2700\u2009ng\/mL) and five times the\n                    <jats:italic>C<\/jats:italic>\n                    <jats:sub>max<\/jats:sub>\n                    (13,500\u2009ng\/mL), and mosquito survival was monitored for 10\u2009days. CLO had no mosquito\u2010lethal effect on\n                    <jats:italic>An.\u2009dirus<\/jats:italic>\n                    . The IVM and CLO co\u2010feed experiment did not indicate any altered effect of IVM on mosquito survival when co\u2010fed with CLO. IVM\u2010CLO livestock co\u2010formulations would not likely alter the\n                    <jats:italic>Anopheles<\/jats:italic>\n                    mosquito\u2010lethal effect of MITL. The use of MITL\u2010CLO for malaria control would have health benefits for livestock, treating helminth and liver fluke infections, and additional One Health benefits by reducing transmission risk of liver flukes to humans.\n                  <\/jats:p>","DOI":"10.1111\/mve.12788","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T08:09:47Z","timestamp":1737360587000},"page":"393-397","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Potential interaction between clorsulon and ivermectin for malaria vector control"],"prefix":"10.1111","volume":"39","author":[{"given":"Thitipong","family":"Hongsuwong","sequence":"first","affiliation":[{"name":"Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine Mahidol University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pattarapon","family":"Khemrattrakool","sequence":"additional","affiliation":[{"name":"Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine Mahidol University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theerawit","family":"Phanphoowong","sequence":"additional","affiliation":[{"name":"Department of Medical Entomology, Faculty of Tropical Medicine Mahidol University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2065-0660","authenticated-orcid":false,"given":"Patchara","family":"Sriwichai","sequence":"additional","affiliation":[{"name":"Department of Medical Entomology, Faculty of Tropical Medicine Mahidol University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kittiyod","family":"Poovorawan","sequence":"additional","affiliation":[{"name":"Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine Mahidol University  Bangkok Thailand"},{"name":"Department of Clinical Tropical Medicine, Faculty of Tropical Medicine Mahidol University  Ratchathewi, Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel","family":"Tarning","sequence":"additional","affiliation":[{"name":"Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine Mahidol University  Bangkok Thailand"},{"name":"Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine University of Oxford  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4807-9681","authenticated-orcid":false,"given":"Kevin C.","family":"Kobylinski","sequence":"additional","affiliation":[{"name":"Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine Mahidol University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,20]]},"reference":[{"key":"e_1_2_12_2_1","first-page":"283","article-title":"Comparative bioavailability of clorsulon after administration of two injectable combinations of ivermectin and clorsulon to cattle","volume":"29","author":"Allix V.","year":"2006","journal-title":"Journal of Veterinary Pharmacology and Therapeutics"},{"key":"e_1_2_12_3_1","unstructured":"Boehringer Ingelheim Animal Health. 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