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The most efficient way to control their populations is through application in breeding sites of highly toxic insecticides that can also impact non\u2010target organisms and generate resistant populations. Therefore, the use of compounds is desirable. Morin hydrate has broad pharmacological applications based on its antioxidant potential, in addition to not having negative effects on mammals. Therefore, the objective of the present study was to investigate the effects of morin hydrate on\n                    <jats:italic>A.\u2009aegypti<\/jats:italic>\n                    survival, pupation rate, egg laying, triacylglycerol reserves and expression of proteins related to lipid metabolism 24\u2009h after exposure of larvae. For this, rearing media containing\n                    <jats:italic>A.\u2009aegypti<\/jats:italic>\n                    larvae with different concentrations of morin hydrate were formulated to evaluate the lethal concentration. Calculation of the expected lethal concentrations showed LC\n                    <jats:sub>25<\/jats:sub>\n                    of 52.692\u2009\u03bcM, LC\n                    <jats:sub>40<\/jats:sub>\n                    of 111.121\u2009\u03bcM, LC\n                    <jats:sub>50<\/jats:sub>\n                    of 174.775\u2009\u03bcM, LC\n                    <jats:sub>75<\/jats:sub>\n                    of 575.083\u2009\u03bcM and LC\n                    <jats:sub>90<\/jats:sub>\n                    of 1685.936\u2009\u03bcM. Twenty\u2010four hours after treatment with morin hydrate, surviving larvae were transferred to morin\u2010free water with food, and their pupation rate and fertility were evaluated. We observed that an increase in the concentration of morin hydrate induced a dose\u2010dependent reduction in survival, doubled pupation time in survivors and reduced the number of eggs laid by treated females during the larval stage by approximately 30% at concentrations exceeding 100\u2009\u03bcM. From this, the impact of 24\u2009h on the triacylglycerol (TAG) stock was evaluated, in addition to evaluating the expression of proteins involved in lipid metabolism. Larvae 24\u2009h after treatment with 100\u2009\u03bcM morin showed a reduction in TAG reserves of approximately 17%, while at 175\u2009\u03bcM, there was a reduction of more than 33% in stocks, and at 500\u2009\u03bcM there was a reduction of 61%. Furthermore, the lipolytic proteins TAGL1 and HSL were upregulated, while the lipogenic proteins FAS1, DGAT1 and GPAT1 were downregulated. Insulin\u2010like receptors were also downregulated, unlike AKHr, which was also upregulated. These data demonstrate that morin hydrate reduces the survival and fertility of\n                    <jats:italic>A.\u2009aegypti<\/jats:italic>\n                    by affecting its lipid metabolism. Morin hydrate did not exhibit toxicity toward non\u2010target organisms, demonstrating interesting potential for the control of mosquito populations.\n                  <\/jats:p>","DOI":"10.1111\/mve.12805","type":"journal-article","created":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T03:10:36Z","timestamp":1745032236000},"page":"592-602","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Morin hydrate reduces survival and fertility, delays development and weakens lipid reserves in\n                    <i>Aedes aegypti<\/i>"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2333-210X","authenticated-orcid":false,"given":"Luan Valim","family":"dos Santos","sequence":"first","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Instituto de Qu\u00edmica Universidade Federal Rural do Rio de Janeiro  Serop\u00e9dica 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