{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T14:06:53Z","timestamp":1786716413870,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005632","name":"Narodowe Centrum Bada\u0144 i Rozwoju","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005632","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004569","name":"Ministerstwo Edukacji i Nauki","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["resjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medical Vet Entomology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The blow fly\n                    <jats:italic>Lucilia sericata<\/jats:italic>\n                    is a medically and veterinary important species whose control increasingly requires environmentally safe alternatives to synthetic insecticides. This study evaluated the effects of 2\u2010octenoic acid (C8:1), a medium\u2010chain unsaturated fatty acid, on the survival, development and physiological integrity of\n                    <jats:italic>L. sericata<\/jats:italic>\n                    larvae and adults. Topical application of C8:1 caused significant mortality and developmental delays in a dose\u2010dependent manner, with LD50 and LD100 values indicating greater susceptibility in larvae than in adults. Cuticular lipid profiling revealed profound alterations in free fatty acid (FFA) and sterol composition following treatment. Larvae exhibited progressive accumulation of medium\u2010 and long\u2010chain FFAs (notably C16:0, C18:0 and C14:1) and depletion of cholesterol, suggesting weakened barrier integrity. In adults, sublethal exposure (LD50) resulted in marked lipid enrichment and incorporation of exogenous C8:1, followed by almost complete depletion of FFAs and cholesterol at lethal doses (LD100), reflecting metabolic collapse. Ethanol (solvent) treatment had minor effects compared with the strong lipid disruptions caused by C8:1. Haemocyte analyses demonstrated dose\u2010dependent immunotoxicity, including granulocyte depletion, cytoplasmic shrinkage and increased proportions of plasmatocytes and oenocytoids, indicating impaired phagocytic and encapsulation responses. These combined effects\u2014cuticular lipid disorganization, cholesterol depletion and haemocyte damage\u2014suggest that 2\u2010octenoic acid compromises both physical and immune defenses. The findings identify 2\u2010octenoic acid as a promising bio\u2010based insecticidal compound with multiple, non\u2010neurotoxic modes of action, offering potential for integrated management of blow fly infestations while reducing risks associated with conventional insecticides.\n                  <\/jats:p>","DOI":"10.1111\/mve.70068","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T03:49:57Z","timestamp":1775533797000},"page":"618-633","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Insecticidal and immunotoxic actions of 2\u2010octenoic acid in the green bottle fly\n                    <i>Lucilia sericata<\/i>\n                    (\n                    <scp>Diptera: Calliphoridae<\/scp>\n                    )"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7319-7973","authenticated-orcid":false,"given":"Agata","family":"Kaczmarek","sequence":"first","affiliation":[{"name":"Museum and Institute of Zoology PAS  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mieczys\u0142awa Irena","family":"Bogu\u015b","sequence":"additional","affiliation":[{"name":"Museum and Institute of Zoology PAS  Warsaw Poland"},{"name":"Biomibo  Warsaw 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