{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:56:40Z","timestamp":1785859000191,"version":"3.56.0"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["resjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medical Vet Entomology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Chronic wounds, particularly in diabetic patients, represent a major clinical and economic burden on healthcare systems worldwide. Complementary therapies are increasingly integrated alongside conventional treatments to improve healing outcomes. Maggot debridement therapy (MDT), utilizing the larvae of\n                    <jats:italic>Lucilia sericata<\/jats:italic>\n                    , is a globally recognized method for treating non\u2010healing wounds. These larvae secrete substances with antifungal, antibacterial and anti\u2010inflammatory properties. Herbal remedies also play a role in chronic wound care, with various Achillea species traditionally used for medicinal purposes. This study investigated the wound healing effects of a pomade combining\n                    <jats:italic>L. sericata<\/jats:italic>\n                    larval secretions and\n                    <jats:italic>Achillea sintenisii<\/jats:italic>\n                    plant extract, compared to Furacin\u00ae, a commercial wound healing cream. Excisional wounds were created on diabetic Wistar albino rats, which were divided into four groups: DF (Furacin\u00ae), DM (\n                    <jats:italic>L. sericata<\/jats:italic>\n                    secretion), DA (\n                    <jats:italic>A. sintenisii<\/jats:italic>\n                    extract) and DM\u2009+\u2009DA (combined). Wound area, contraction rates and histological parameters were assessed at Days 0, 4, 8 and 12. Wound area decreased significantly across all groups over time (\n                    <jats:italic>F<\/jats:italic>\n                    \u2009=\u2009511.9,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001), with mean values declining from 11.11\u2009cm\n                    <jats:sup>2<\/jats:sup>\n                    at Day 0 to 7.44\u2009cm\n                    <jats:sup>2<\/jats:sup>\n                    at Day 4, 4.93\u2009cm\n                    <jats:sup>2<\/jats:sup>\n                    at Day 8 and 2.01\u2009cm\n                    <jats:sup>2<\/jats:sup>\n                    at Day 12. Contraction rates rose progressively across all groups (\n                    <jats:italic>F<\/jats:italic>\n                    \u2009=\u2009169.3,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001): at Day 4, contraction rates were 20.41%\u2009\u00b1\u20091.24% (DF), 43.29%\u2009\u00b1\u20093.96% (DM), 27.67%\u2009\u00b1\u20090.94% (DA) and 42.22%\u2009\u00b1\u20091.20% (DM\u2009+\u2009DA); at Day 8, rates increased to 42.86%\u2009\u00b1\u20091.11% (DF), 63.34\u2009\u00b1\u20090.92% (DM), 52.97%\u2009\u00b1\u20090.55% (DA) and 63.26%\u2009\u00b1\u20090.52% (DM\u2009+\u2009DA) and at Day 12, the DM\u2009+\u2009DA group achieved the highest contraction rate of 92.91%\u2009\u00b1\u20090.40%, significantly surpassing all other groups\u2014DM (84.30%\u2009\u00b1\u20090.88%), DA (79.43\u2009\u00b1\u20090.61%) and DF (71.77%\u2009\u00b1\u20090.64%)\u2014demonstrating a clear synergistic effect of the combined therapy (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Histological evaluation further corroborated these findings, with the DM\u2009+\u2009DA group consistently achieving the highest scores across all tissue repair parameters (epithelialization, fibroblast density, collagen deposition, angiogenesis and hair follicle regeneration), significantly superior to all other groups (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Taken together, these results confirm that the combination of\n                    <jats:italic>L. sericata<\/jats:italic>\n                    secretions and\n                    <jats:italic>A. sintenisii<\/jats:italic>\n                    extract exerts a synergistic wound healing effect superior to either agent alone or to Furacin\u00ae and could lead to the development of affordable, accessible and effective natural products for chronic wound care. These results may contribute to innovative treatment options in both veterinary and human medicine.\n                  <\/jats:p>","DOI":"10.1111\/mve.70075","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T06:19:01Z","timestamp":1778048341000},"page":"659-671","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Histopathological investigation of wound healing activities of\n                    <i>Lucilia sericata<\/i>\n                    Larva and\n                    <i>Achillea sintenisii<\/i>\n                    extract combinations in diabetic rat wound model"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2982-2396","authenticated-orcid":false,"given":"Nevra","family":"Polat","sequence":"first","affiliation":[{"name":"Department of Traditional Complementary and Integrative Medicine, Institute of Public Health Ankara Y\u0131ld\u0131r\u0131m Beyaz\u0131t University  Ankara Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7384-4106","authenticated-orcid":false,"given":"Salih","family":"Mollahalilo\u011flu","sequence":"additional","affiliation":[{"name":"Department of Public Health, Faculty of Medicine Ankara Y\u0131ld\u0131r\u0131m Beyaz\u0131t University  Ankara Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0829-4571","authenticated-orcid":false,"given":"Murat","family":"Ko\u00e7","sequence":"additional","affiliation":[{"name":"Department of Traditional Complementary and Integrative Medicine, Institute of Public Health Ankara Y\u0131ld\u0131r\u0131m Beyaz\u0131t University  Ankara Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2011.03.073"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/nep039"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.30498\/IJB.2019.92707"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-020-05141-y"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24119774"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2022.104426"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13355-013-0181-7"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8111845"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.5667\/tang.2012.0025"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.5772\/65521"},{"key":"e_1_2_10_12_1","volume-title":"Botanica","author":"Cheers G.","year":"1999"},{"key":"e_1_2_10_13_1","unstructured":"Do\u011fandemir G.(2010)Lucilia sericata'n\u0131n Kronik Yaralarda Kolonize Olan Mikroorganizmalar \u00dczerindeki Antimikrobiyal Etkinli\u011finin Ara\u015ft\u0131r\u0131lmas\u0131. 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