{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T09:31:55Z","timestamp":1789810315652,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,11,22]],"date-time":"2012-11-22T00:00:00Z","timestamp":1353542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Because published reports indicate that the antibiotic colistin (COL) has antifungal properties, this study investigated the antifungal <jats:italic>in vitro<\/jats:italic> activity of COL as single agent and in combination with the antifungal compounds voriconazole (VRC), caspofungin (CAS) and amphotericin B (AMB) against <jats:italic>Scedosporium\/Pseudallescheria<\/jats:italic> spp., <jats:italic>Exophiala dermatitidis<\/jats:italic> and <jats:italic>Geosmithia argillacea<\/jats:italic>. In total, susceptibility was determined for 77 <jats:italic>Scedosporium\/Pseudallescheria<\/jats:italic> spp., 82 <jats:italic>E. dermatitidis<\/jats:italic> and 17 <jats:italic>G. argillacea<\/jats:italic> isolates. The minimal inhibitory concentrations (MICs) of COL and the antifungals as single compound and in combination were determined with MIC test strips. Drug interactions were detected by crossing the MIC test strips at a 90\u00ba angle. The fractional inhibitory concentration index was used to categorise the drugs\u2019 interaction. The MIC<jats:sub>50<\/jats:sub> value of COL was 12\u2003\u03bcg\u2003ml<jats:sup>\u22121<\/jats:sup> for <jats:italic>S. prolificans<\/jats:italic>, 16\u2003\u03bcg\u2003ml<jats:sup>\u22121<\/jats:sup> for <jats:italic>P. apiosperma<\/jats:italic>, 16\u2003\u03bcg\u2003ml<jats:sup>\u22121<\/jats:sup> for <jats:italic>P. boydii<\/jats:italic>, 12\u2003\u03bcg\u2003ml<jats:sup>\u22121<\/jats:sup> for <jats:italic>E. dermatiditis<\/jats:italic> and 6\u2003\u03bcg\u2003ml<jats:sup>\u22121<\/jats:sup> for <jats:italic>G. argillacea<\/jats:italic>. VRC was the most active drug in combination without any antagonism with the exception of few <jats:italic>P. boydii<\/jats:italic> isolates. COL as single agent and in most combinations with antifungals exhibits <jats:italic>in vitro<\/jats:italic> antifungal activity against filamentous ascomycetes occurring in cystic fibrosis patients and may offer a novel therapeutic option, especially for multidrug\u2010resistant <jats:italic>S. prolificans<\/jats:italic>.<\/jats:p>","DOI":"10.1111\/myc.12022","type":"journal-article","created":{"date-parts":[[2012,11,22]],"date-time":"2012-11-22T06:10:19Z","timestamp":1353564619000},"page":"297-303","source":"Crossref","is-referenced-by-count":31,"title":["<i>In vitro<\/i> activity of colistin as single agent and in combination with antifungals against filamentous fungi occurring in patients with cystic fibrosis"],"prefix":"10.1111","volume":"56","author":[{"given":"H.","family":"Schemuth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Dittmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Lackner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Sedlacek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Hamprecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Steinmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Buer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.\u2010M.","family":"Rath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Steinmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,11,22]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00068-09"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0507.2003.00830.x"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/13693780802609604"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00184-10"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00047-10"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.3109\/13693786.2010.511287"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s100960050011"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00039-07"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq250"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02113255"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01840-09"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/13693780802524506"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2007.01.011"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2005.12.011"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.3121\/cmr.4.2.138"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2009.03.001"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq046"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00956-09"},{"key":"e_1_2_7_20_2","first-page":"475","article-title":"Discrimination of Scedosporium prolificans against Pseudallescheria boydii and Scedosporium apiospermum by semiautomated repetitive sequence\u2010based PCR","volume":"49","author":"Steinmann J","year":"2011","journal-title":"Med Mycol"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05910-11"},{"key":"e_1_2_7_22_2","volume-title":"Reference Method for Broth Microdilution Antifungal Susceptibility Testing of Filamentous Fungi; 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