{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T02:06:47Z","timestamp":1780106807996,"version":"3.54.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,12,10]],"date-time":"2012-12-10T00:00:00Z","timestamp":1355097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Repeated and prolonged use of fluconazole in treating candidosis leads to drug resistance. The aim of this study was to confirm the relationship between T916C (Y257H) mutation in<jats:italic>Candida albicans ERG11<\/jats:italic>and fluconazole resistance. We replaced one copy of<jats:italic>ERG11<\/jats:italic>with<jats:italic>ERG11<\/jats:italic>containing the T916C mutation in<jats:italic>C. albicans<\/jats:italic>CAI4 and expressed<jats:italic>ERG11<\/jats:italic>with the T916C mutation in<jats:italic>Saccharomyces cerevisiae<\/jats:italic>INVSc1. The MIC values were two\u2010 to four\u2010fold greater in CAI4 transformants with than without the T916C mutation and 128 and 32\u2003\u03bcg\u2003ml<jats:sup>\u22121<\/jats:sup>for<jats:italic>S. cerevisiae<\/jats:italic>INVSc1\u2010containing<jats:italic>ERG11<\/jats:italic>with and without the T916C mutation. T916C mutation may be associated with fluconazole resistance in<jats:italic>C. albicans<\/jats:italic>.<\/jats:p>","DOI":"10.1111\/myc.12027","type":"journal-article","created":{"date-parts":[[2012,12,10]],"date-time":"2012-12-10T10:50:04Z","timestamp":1355136604000},"page":"315-320","source":"Crossref","is-referenced-by-count":9,"title":["Association of T916C (Y257H) mutation in<i>Candida albicans ERG11<\/i>with fluconazole resistance"],"prefix":"10.1111","volume":"56","author":[{"given":"Jie","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,10]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2009.01766.x"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021239"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn015"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.1.63-67.2000"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.9.5682"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.27237-0"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7909170"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/jobm.200510133"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fgb.2004.08.001"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.13"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/147323001003800216"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-3274-3_21"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.6.1704-1713.2002"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.10.6023-6031.2004"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/46.3.397"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00348-10"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks186"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2009.11.006"},{"key":"e_1_2_7_21_2","doi-asserted-by":"crossref","first-page":"544","DOI":"10.3760\/cma.j.issn.0366-6999.2010.05.007","article-title":"Relationship between antifungal resistance of fluconazole resistant Candida albicans and mutations in ERG11 gene","volume":"123","author":"Feng LJ","year":"2010","journal-title":"Chin Med J (Engl)"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.6.2124-2131.2004"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.2.568-574.2004"},{"key":"e_1_2_7_24_2","first-page":"360","article-title":"Synergistic effect of terbinafine combined with fluconazole or itraconazole on stable fluconazole\u2010resistant Candida albicans induced by fluconazole in vitro","volume":"26","author":"Jiang W","year":"2006","journal-title":"Chin J Microbiol Immunol"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2004.10506984"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.11.2985-2990.2000"},{"key":"e_1_2_7_27_2","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1128\/AAC.42.2.241","article-title":"Amino acid 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