{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T14:44:32Z","timestamp":1704293072055},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,1,8]],"date-time":"2013-01-08T00:00:00Z","timestamp":1357603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Onychomycosis constitutes up to 50% of all nail disorders. Toenails are generally affected, mostly due to dermatophytes. Terbinafine is the most potent antifungal agent <jats:italic>in vitro<\/jats:italic> against dermatophytes. There are few randomised controlled trials using a non\u2010continuous dose of terbinafine. The aim of this open\u2010label pilot study was to reduce the total drug amount, the collateral effects and, specially, the costs; albeit maintaining the same efficacy of the standard regimens. Compare the outcomes of two different intermittent regimens with the same total amount of the medication (42 tablets in 6\u2003months). Forty\u2010one patients were divided into the following groups: terbinafine 250\u2003mg\u2003day<jats:sup>\u22121<\/jats:sup>, for 7\u2003days, monthly or terbinafine 500\u2003mg\u2003day<jats:sup>\u22121<\/jats:sup>, once daily, for 7\u2003days, every 2\u2003months, both plus nail abrasion during 6\u2003months. The efficacy was evaluated at months 6, 12 and 18 using the <jats:italic>disease free nail<\/jats:italic> criteria. Total cure\u2003=\u2003group I: eight patients (44.4%) and group II: eight patients (44.4%). Partial cure\u2003=\u2003group I: five patients (27.8%) and group II: four patients (22.2%). Treatment failure\u2003=\u2003group I: five patients (27.8%) and group II: three patients (16.7%). Recurrence\u2003=\u2003group I: zero patients (0.0%) and group II: three patients (16.7%). Two intermittent dosing regimens of terbinafine plus nail abrasion proved to be an alternative statistically effective, safe and with reduced drug costs for dermatophytes toenail onychomycosis.<\/jats:p>","DOI":"10.1111\/myc.12032","type":"journal-article","created":{"date-parts":[[2013,1,8]],"date-time":"2013-01-08T17:14:56Z","timestamp":1357665296000},"page":"327-332","source":"Crossref","is-referenced-by-count":15,"title":["Intermittent therapy with terbinafine and nail abrasion for dermatophyte toe onychomycosis: a pilot study"],"prefix":"10.1111","volume":"56","author":[{"given":"Isabella B.","family":"Succi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9a R.","family":"Bernardes\u2010Engemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosane","family":"Orofino\u2010Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,8]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2007.02480.x"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.09.001"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05242.x"},{"key":"e_1_2_8_5_2","first-page":"679","article-title":"Prognostic factors for cure following treatment of onichomycosis","volume":"24","author":"Sigurgeirsson B","year":"2010","journal-title":"JEADV"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200304010-00005"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962003000400006"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-46652002000500013"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.01.016"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yadr.2006.07.001"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2009.12.006"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2006.00176.x"},{"key":"e_1_2_8_13_2","first-page":"256","article-title":"The use of an intermittent terbinafine regimen for the treatment of dermatophyte toenail onychomycosis","volume":"23","author":"Gupta AK","year":"2009","journal-title":"JEADV"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/120347540400800107"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2007.03.021"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.149.s65.3.x"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2130.2004.00095.x"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.140.6.691"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1996.tb04009.x"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.04.055"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2003.01678.x"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(03)00339-6"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-008-9109-0"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-200724040-00003"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.7547\/0960465"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fmyc.12032","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.12032","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T19:33:04Z","timestamp":1698694384000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.12032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,8]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["10.1111\/myc.12032"],"URL":"https:\/\/doi.org\/10.1111\/myc.12032","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,8]]}}}