{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T22:39:36Z","timestamp":1778539176643,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,4,16]],"date-time":"2013-04-16T00:00:00Z","timestamp":1366070400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Onychomycosis is a common fungal infection most often affecting the toenails. If untreated, it can cause discomfort sufficient to reduce quality of life. To evaluate efficacy and safety of bifonazole cream vs. placebo in onychomycosis treatment after non\u2010surgical nail ablation with urea paste. Fifty\u2010one study centres randomized 692 subjects with mild\u2010to\u2010moderate onychomycosis to receive bifonazole 1% cream or placebo for 4\u2003weeks following non\u2010surgical nail ablation with urea 40% paste over 2\u20134\u2003weeks. Efficacy of the two phase treatment was evaluated by overall cure of the target nail comprising clinical and mycological cure 2\u2003weeks, 3 and 6\u2003months after end of treatment. At 2\u2003weeks (primary endpoint), overall cure rate was superior in bifonazole\u2010treated group (54.8% vs. 42.2% for placebo; <jats:italic>P<\/jats:italic>\u2003=\u20030.0024). The clinical cure rate was high in both treatment groups (86.6% bifonazole vs. 82.8% placebo), but proportion with mycological cure was higher with bifonazole treatment (64.5%) vs. placebo treatment 49.0%, (<jats:italic>P<\/jats:italic>\u2003=\u20030.0001). We observed higher early overall cure rate with 4\u2003weeks topical bifonazole compared with placebo after removal of infected nail parts with urea. This two stage treatment was well tolerated and offers an additional option in topical onychomycosis therapy.<\/jats:p>","DOI":"10.1111\/myc.12037","type":"journal-article","created":{"date-parts":[[2013,4,16]],"date-time":"2013-04-16T09:00:41Z","timestamp":1366102841000},"page":"414-421","source":"Crossref","is-referenced-by-count":22,"title":["Efficacy of 4\u2003weeks topical bifonazole treatment for onychomycosis after nail ablation with 40% urea: a double\u2010blind, randomized, placebo\u2010controlled multicenter 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