{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:28:21Z","timestamp":1792038501674,"version":"4.4.0"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Although the consequences of invasive fungal infections (IFIs) secondary to chronic hepatitis B infections secondary IFIs are serious, the incidence and main pathogenic factors of IFIs in acute\u2010on\u2010chronic liver failure (ACLF) patients remain unclear. This study included 1200 hepatitis B patients who were treated in the Department of Infectious Diseases, Shanghai Changzheng Hospital from January 2006 to January 2009. Patients with ACLF were screened according to the diagnostic guidelines for liver failure. Patients with ACLF and secondary IFI were the disease group, and patients with ACLF without secondary IFI were the controls. The incidence of IFI, mortality, and possible IFI causes in two groups were evaluated retrospectively. Sixty patients with ACLF had secondary IFI, of which 14 were confirmed cases and 46 were suspected cases. The incidence of IFI was 47.62% for ACLF patients. Logistic regression analysis showed that the level of hepatitis B viral (HBV) DNA was an important risk factor for secondary IFI in ACLF patients. Receiver operating characteristic curve analysis suggested that when the number of HBV DNA copies was higher than 3.16\u2003\u00d7\u200310<jats:sup>3<\/jats:sup>\u2003copies\u2003ml<jats:sup>\u22121<\/jats:sup>, the possibility of secondary IFI in ACLF patients increased significantly, while white blood cell levels showed protective effects for these patients. The incidence of IFI is high in ACLF patients and high hepatitis B virus DNA levels may be an independent risk factor of secondary IFI in these patients.<\/jats:p>","DOI":"10.1111\/myc.12044","type":"journal-article","created":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T16:16:57Z","timestamp":1359735417000},"page":"429-433","source":"Crossref","is-referenced-by-count":31,"title":["Invasive fungal infections secondary to acute\u2010on\u2010chronic liver failure: a retrospective study"],"prefix":"10.1111","volume":"56","author":[{"given":"Li Na","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu Bin","family":"Che","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju Lin","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang Han","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,2]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-008-9106-x"},{"key":"e_1_2_9_3_2","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1177\/135965350601100614","article-title":"Hepatitis B virus replication and liver disease progression: the impact of antiviral therapy","volume":"11","author":"Liaw YF","year":"2006","journal-title":"Antivir Ther"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0676.1986.tb00295.x"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840080520"},{"key":"e_1_2_9_6_2","first-page":"643","article-title":"Diagnostic and treatment guidelines for liver failure","volume":"14","author":"Liver Failure and Artificial Liver Group, Chinese Society of Infectious Diseases, Chinese Medical Association; Severe Liver Diseases and Artificial Liver Group, Chinese Society of Hepatology, Chinese Medical Association","year":"2006","journal-title":"Zhonghua Gan Zang Bing Za Zhi"},{"key":"e_1_2_9_7_2","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1086\/588660","article-title":"Revised definitions of invasive fungal disease from the European organization for research and treatment of cancer\/invasive fungal infections cooperative group and the national institute of allergy and infectious diseases mycoses study group (EORTC\/MSC) consensus group","volume":"46","author":"Ben De P","year":"2008","journal-title":"Clin Infect Dis"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(91)90900-V"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.4236\/health.2011.31008"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1007252"},{"key":"e_1_2_9_11_2","first-page":"165","article-title":"Fungal infection in the course of acute liver failure","volume":"13","author":"Kup\u015b J","year":"2002","journal-title":"Pol Merkur Lekarski"},{"key":"e_1_2_9_12_2","first-page":"214","article-title":"Analysis of risk factors of patients with chronic liver failure complicated invasive fungal infections","volume":"23","author":"Hu YR","year":"2009","journal-title":"Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.4.1829-1835.2005"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20667"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1086\/497138"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1086\/432060"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2006.01388.x"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12281-008-0005-3"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-008-9067-0"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00396-05"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21482"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.02.033"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fmyc.12044","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.12044","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T18:26:05Z","timestamp":1696271165000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.12044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1111\/myc.12044"],"URL":"https:\/\/doi.org\/10.1111\/myc.12044","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2]]}}}