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Isoconazole nitrate (<jats:styled-content style=\"fixed-case\">ISN<\/jats:styled-content>) is a broad\u2010spectrum antimicrobial agent with a highly effective antimycotic and gram\u2010positive antibacterial activity, a rapid rate of absorption and low systemic exposure potential. <jats:styled-content style=\"fixed-case\">ISN<\/jats:styled-content> is effective against pathogens involved in dermatomycoses, with minimum inhibitory concentrations well below the concentration of <jats:styled-content style=\"fixed-case\">ISN<\/jats:styled-content> in skin and hair follicles. The combination of the corticosteroid diflucortolone valerate with <jats:styled-content style=\"fixed-case\">ISN<\/jats:styled-content> (Travocort<jats:sup>\u00ae<\/jats:sup>) increases the local bioavailability of <jats:styled-content style=\"fixed-case\">ISN<\/jats:styled-content>. Compared with <jats:styled-content style=\"fixed-case\">ISN<\/jats:styled-content> monotherapy, Travocort has a faster onset of antimycotic action, faster relief of itch and other inflammatory symptoms, improved overall therapeutic benefits and earlier mycological cure rate. Travocort is effective in the treatment of inflammatory mycotic infections, and also in the eradication of accompanied gram\u2010positive bacterial infections. The rapid improvement observed with Travocort treatment, combined with favourable safety and tolerability, results in higher patient satisfaction, and therefore, can be an effective tool to increase treatment adherence in patients with dermatomycoses accompanied by inflammatory signs and symptoms.<\/jats:p>","DOI":"10.1111\/myc.12054","type":"journal-article","created":{"date-parts":[[2013,4,10]],"date-time":"2013-04-10T10:22:00Z","timestamp":1365589320000},"page":"3-15","source":"Crossref","is-referenced-by-count":31,"title":["Isoconazole nitrate: a unique broad\u2010spectrum antimicrobial azole effective in the treatment of dermatomycoses, both as monotherapy and in combination with corticosteroids"],"prefix":"10.1111","volume":"56","author":[{"given":"Stefano","family":"Veraldi","sequence":"first","affiliation":[{"name":"Department of Pathophysiology and Transplantation University of Milan I.R.C.C.S. 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