{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T06:56:58Z","timestamp":1777100218103,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,2,24]],"date-time":"2013-02-24T00:00:00Z","timestamp":1361664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Data on diagnostic performance of Galactomannan (<jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content>) testing in patients under mould\u2010active regimens are limited. Whether sensitivity of <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> testing for diagnosing breakthrough invasive aspergillosis (IA) is decreased under antifungal prophylaxis\/therapy remains therefore a point of discussion. We retrospectively analysed <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> test results in patients who were admitted with underlying haematological malignancies to two Divisions of the Medical University Hospital of Graz, Austria, between 2009 and 2012. Only cases of probable and proven <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> that were diagnosed by other methods than <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> testing were included (time of diagnosis\u00a0=\u00a0day 0). We compared <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> results of patients with\/without therapy\/prophylaxis for the period of 2\u00a0weeks prior (week \u22122) until 3\u00a0weeks postdiagnosis. A total of 76 <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> test results in nine patients were identified. Six patients had received antifungal therapy\/prophylaxis from week \u22122, whereas three patients were treated with therapy from the time of diagnosis at week 0. <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> testing was positive in 45\/76 (59%) of samples. Sensitivity of <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> testing for detection of proven or probable <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> at week \u22121 and 0 was 77% and 79% in patients with mould\u2010active regimens. We conclude that <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> testing might be a useful diagnostic method for breakthrough <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> in patients receiving mould\u2010active prophylaxis\/therapy.<\/jats:p>","DOI":"10.1111\/myc.12060","type":"journal-article","created":{"date-parts":[[2013,2,25]],"date-time":"2013-02-25T03:22:40Z","timestamp":1361762560000},"page":"471-476","source":"Crossref","is-referenced-by-count":41,"title":["Sensitivity of galactomannan enzyme immunoassay for diagnosing breakthrough invasive aspergillosis under antifungal prophylaxis and empirical therapy"],"prefix":"10.1111","volume":"56","author":[{"given":"Martin","family":"Hoenigl","sequence":"first","affiliation":[{"name":"Section of Infectious Diseases Division of Pulmonology Medical University of Graz Graz 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