{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T12:56:46Z","timestamp":1780577806315,"version":"3.54.1"},"reference-count":49,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,3,17]],"date-time":"2013-03-17T00:00:00Z","timestamp":1363478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The State of Cear\u00e1 in north\u2010eastern Brazil has one of the highest rates in the world of relapse and death due to disseminated histoplasmosis (<jats:styled-content style=\"fixed-case\">DH<\/jats:styled-content>) in acquired immunodeficiency syndrome (<jats:styled-content style=\"fixed-case\">AIDS<\/jats:styled-content>) patients. The objective of this study is to characterise the relapse and mortality of <jats:styled-content style=\"fixed-case\">DH<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">AIDS<\/jats:styled-content> cases residents in Cear\u00e1. We performed a retrospective analysis of the medical records of <jats:styled-content style=\"fixed-case\">AIDS<\/jats:styled-content> patients who had a first episode of <jats:styled-content style=\"fixed-case\">DH<\/jats:styled-content> from 2002 to 2008. We analysed the outcomes until December 31, 2010. A total of 145 patients participated in the study. The mean clinical follow\u2010up duration was 3.38\u00a0years (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\u00a0=\u00a02.2; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a03.01\u20133.75). The majority of the subjects were male with a mean age of 35\u00a0years (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\u00a0=\u00a02.2; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a03.01\u20133.75) and were born in the capital of Cear\u00e1. <jats:styled-content style=\"fixed-case\">DH<\/jats:styled-content> was the first manifestation of <jats:styled-content style=\"fixed-case\">AIDS<\/jats:styled-content> in 59% of the patients. The relapse rate was 23.3%, with a disseminated presentation in 90% of these patients. The overall mortality during the study period was 30.2%. The majority of patients who relapsed or died had irregular treatment with antifungals or highly active antiretroviral therapy and did not have active clinical follow\u2010up. High rates of recurrence and mortality were found in <jats:styled-content style=\"fixed-case\">AIDS<\/jats:styled-content>\u2010associated <jats:styled-content style=\"fixed-case\">DH<\/jats:styled-content> in this area of the country.<\/jats:p>","DOI":"10.1111\/myc.12067","type":"journal-article","created":{"date-parts":[[2013,3,18]],"date-time":"2013-03-18T03:58:38Z","timestamp":1363579118000},"page":"520-526","source":"Crossref","is-referenced-by-count":23,"title":["Disseminated histoplasmosis and aids: relapse and late mortality in endemic area in north\u2010eastern Brazil"],"prefix":"10.1111","volume":"56","author":[{"given":"Lisandra Serra","family":"Dasmasceno","sequence":"first","affiliation":[{"name":"Department of Community Health School of Medicine Federal University of Cear\u00e1 Fortaleza CE Brazil"},{"name":"Hospital S\u00e3o Jos\u00e9 of Infectious Diseases Health Department of Cear\u00e1 Fortaleza CE Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto Ramos","family":"Novaes Jr","sequence":"additional","affiliation":[{"name":"Department of Community Health School of Medicine Federal University of Cear\u00e1 Fortaleza CE Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Henrique Morais","family":"Alencar","sequence":"additional","affiliation":[{"name":"Department of Community Health School of Medicine Federal University of Cear\u00e1 Fortaleza CE Brazil"},{"name":"Swiss Tropical and Public Health Institute University of Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Teixeira","family":"Lima","sequence":"additional","affiliation":[{"name":"Specialized Medical Mycology Center Federal University of Cear\u00e1 Fortaleza CE Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 J\u00falio Costa","family":"Sidrim","sequence":"additional","affiliation":[{"name":"Specialized Medical Mycology Center Federal University of Cear\u00e1 Fortaleza CE Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria V\u00e2nia Freitas","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Hospital S\u00e3o Jos\u00e9 of Infectious Diseases Health Department of Cear\u00e1 Fortaleza CE Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jac\u00f3 Ricarte Lima","family":"de Mesquita","sequence":"additional","affiliation":[{"name":"Hospital S\u00e3o Jos\u00e9 of Infectious Diseases Health Department of Cear\u00e1 Fortaleza CE Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terezinha do Menino Jesus Silva","family":"Leit\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Community Health School of Medicine Federal University of Cear\u00e1 Fortaleza CE Brazil"},{"name":"Hospital S\u00e3o Jos\u00e9 of Infectious Diseases Health Department of Cear\u00e1 Fortaleza CE Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,17]]},"reference":[{"issue":"1","key":"e_1_2_7_2_1","first-page":"1","article-title":"1987 revision of the CDC surveillance case definition for acquired immunodeficiency syndrome","volume":"36","author":"Centers for Disease Control and Prevention","year":"1987","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86822009000200020"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00027-06"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/432120"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-46652001000400001"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"576","DOI":"10.4269\/ajtmh.2005.73.576","article-title":"Disseminated histoplasmosis: a comparative study between patients with acquired immunodeficiency syndrome and non\u2010human immunodeficiency virus\u2010infected individuals","volume":"73","author":"Tobon AM","year":"2005","journal-title":"Am J Trop Med Hyg"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0213-005X(04)73056-6"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1413-86702006000500005"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86822004000600007"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2007.01459.x"},{"key":"e_1_2_7_12_1","first-page":"1","article-title":"Guidelines for prevention and treatment of opportunistic infections in HIV\u2010infected adults and adolescents. Recommendations from CDC, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America","volume":"58","author":"Centers for Disease Control and Prevention","year":"2009","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5520(02)00039-9"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.qco.0000244049.15888.b9"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1086\/428842"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1086\/420749"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86822010000100007"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1086\/345724"},{"key":"e_1_2_7_19_1","first-page":"75","article-title":"Interrupici\u00f3n de la prophilaxis secundaria antifungica em la histoplasmosis asociada al sida","volume":"21","author":"Negroni R","year":"2004","journal-title":"Rev Iberoam Micol"},{"key":"e_1_2_7_20_1","first-page":"546","article-title":"Successful discontinuation of secondary prophylaxis for histoplasmosis after higly active antiretroviral therapy","volume":"103","author":"Sun HY","year":"2004","journal-title":"J Formos Med Assoc"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1086\/313752"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1086\/521259"},{"key":"e_1_2_7_23_1","unstructured":"BRASIL.Minist\u00e9rio da Sa\u00fade. Secretaria de Vigil\u00e2ncia em Sa\u00fade. Programa Nacional de DST e Aids. Crit\u00e9rios de defini\u00e7\u00e3o de casos de AIDS em adultos e crian\u00e7as. Bras\u00edlia: Minist\u00e9rio da Sa\u00fade 2003."},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2007.01894.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"crossref","first-page":"600","DOI":"10.4269\/ajtmh.2006.74.600","article-title":"Risk factors for death in acquired immunodeficiency syndrome\u2010associated disseminated histoplasmosis","volume":"74","author":"De Franchesco Daher E","year":"2006","journal-title":"Am J Trop Med Hyg"},{"key":"e_1_2_7_26_1","unstructured":"BRASIL.Minist\u00e9rio da Sa\u00fade. Secretaria de Vigil\u00e2ncia em Sa\u00fade. Departamento de DST Aids e Hepatites Virais. Boletim Epidemiol\u00f3gico \u2013 AIDS e DST Bras\u00edlia: Minist\u00e9rio da Sa\u00fade 2010."},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3282ffde67"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1086\/379770"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2002.01590.x"},{"key":"e_1_2_7_30_1","unstructured":"CEAR\u00c1.Governo do Estado. Secretaria de Sa\u00fade do Estado. Informe Epidemiol\u00f3gico AIDS.Fortaleza 2011."},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-46652007000100007"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.qai.0000286597.57066.2b"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/00126334-200009010-00010"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1086\/652650"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/00126334-200408010-00009"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-311X2009000600019"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014585"},{"issue":"1","key":"e_1_2_7_38_1","first-page":"579","article-title":"Survival of AIDS in the Southeast and South of Brazil: analysis of the 1998\u20131999 cohort","volume":"27","author":"Guibu AI","year":"2011","journal-title":"Cad Saude Publica"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31821b11ab"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-6405-8-23"},{"key":"e_1_2_7_41_1","first-page":"141","article-title":"Infec\u00e7\u00f5es oportunistas em indiv\u00edduos com infec\u00e7\u00e3o pelo HIV e rela\u00e7\u00e3o com uso de terapia antiretroviral","volume":"32","author":"Fagundes VHV","year":"2010","journal-title":"Acta Sci Health Sci"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2011.10-0251"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1130-1406(05)70027-9"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1413-81232010000700029"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-115-12-936"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2008.05.006"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1L624"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1086\/520978"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283097d0f"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1086\/382675"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fmyc.12067","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.12067","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T23:05:38Z","timestamp":1696287938000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.12067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,17]]},"references-count":49,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["10.1111\/myc.12067"],"URL":"https:\/\/doi.org\/10.1111\/myc.12067","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,17]]}}}