{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T13:32:27Z","timestamp":1751376747793},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,3,18]],"date-time":"2013-03-18T00:00:00Z","timestamp":1363564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2013,9]]},"abstract":"Summary<\/jats:title>Diagnosis of invasive pulmonary aspergillosis (IPA<\/jats:styled-content>) is a challenging process in immunocompromised patients. Galactomannan (GM<\/jats:styled-content>) antigen detection in bronchoalveolar lavage (BAL<\/jats:styled-content>) fluid is a method to detect IPA<\/jats:styled-content> with improved sensitivity over conventional studies. We sought to determine the diagnostic yield of BAL GM<\/jats:styled-content> assay in a diverse population of immunocompromised patients. A retrospective review of 150 fiberoptic bronchoscopy (FOB<\/jats:styled-content>) with BAL<\/jats:styled-content> for newly diagnosed pulmonary infiltrate in immunocompromised patients was performed. Patient information, procedural details and laboratory studies were collected. BAL<\/jats:styled-content> and serum samples were evaluated for GM<\/jats:styled-content> using enzyme\u2010linked immunoassay. Of 150 separate FOB<\/jats:styled-content> with BAL<\/jats:styled-content>, BAL GM<\/jats:styled-content> was obtained in 143 samples. There were 31 positive BAL GM<\/jats:styled-content> assays. In those 31 positive tests, 13 were confirmed as IPA<\/jats:styled-content>, giving a positive predictive value of 41.9%. There was one false negative BAL GM<\/jats:styled-content>. Of the 18 false positive BAL GM<\/jats:styled-content>, 4 were receiving piperacillin\u2013tazobactam and 11 were receiving an alternative beta\u2010lactam antibiotic. BAL GM<\/jats:styled-content> assay shows excellent sensitivity for diagnosing IPA<\/jats:styled-content>. There was a significant number of false positive BAL GM<\/jats:styled-content> assays and several of those patients were receiving beta\u2010lactam antibiotics at the time of bronchoscopy.<\/jats:p>","DOI":"10.1111\/myc.12074","type":"journal-article","created":{"date-parts":[[2013,3,18]],"date-time":"2013-03-18T06:13:13Z","timestamp":1363587193000},"page":"552-558","source":"Crossref","is-referenced-by-count":16,"title":["Utility of galactomannan antigen detection in bronchoalveolar lavage fluid in immunocompromised patients"],"prefix":"10.1111","volume":"56","author":[{"given":"Kyle R.","family":"Brownback","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine University of Kansas Medical Center Kansas City KS USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas R.","family":"Pitts","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine University of Kansas Medical Center Kansas City KS USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven Q.","family":"Simpson","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine University of Kansas Medical Center Kansas City KS 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