{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T07:56:21Z","timestamp":1787990181563,"version":"build-2784847793"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,3,18]],"date-time":"2013-03-18T00:00:00Z","timestamp":1363564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Patients with aspergilloma can be safely managed with supportive therapy in absence of massive haemoptysis. We hypothesised that chronic cavitary pulmonary aspergillosis (\n                    <jats:styled-content style=\"fixed-case\">CCPA<\/jats:styled-content>\n                    ) could also be managed on similar grounds. The aim of this prospective, randomised controlled trial was to evaluate the efficacy and safety of itraconazole in\n                    <jats:styled-content style=\"fixed-case\">CCPA<\/jats:styled-content>\n                    . Consecutive patients of\n                    <jats:styled-content style=\"fixed-case\">CCPA<\/jats:styled-content>\n                    with presence of chronic pulmonary\/systemic symptoms; and pulmonary cavities; and presence of\n                    <jats:italic>Aspergillus<\/jats:italic>\n                    (immunological or microbiological) were randomised to receive either supportive treatment alone or itraconazole 400\u00a0mg daily for 6\u00a0months plus supportive therapy. Response was assessed clinically, radiologically and overall after 6\u00a0months therapy. A total of 31 patients (mean age, 37\u00a0years) were randomised to itraconazole (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a017) or the control (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a014) group. The number of patients showing overall response was significantly higher in the itraconazole group (76.5%) vs. the control (35.7%) group (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.02). The numbers of patients demonstrating clinical or radiological response were also significantly higher in the itraconazole group (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.016 and 0.01 respectively). Adverse events were noted in eight patients in the itraconazole group, however, none was serious or led to discontinuation of the study drug. Itraconazole was found to be superior to standard supportive treatment alone in stabilising cases of\n                    <jats:styled-content style=\"fixed-case\">CCPA<\/jats:styled-content>\n                    . (clinicaltrials.gov; NCT01259336).\n                  <\/jats:p>","DOI":"10.1111\/myc.12075","type":"journal-article","created":{"date-parts":[[2013,3,18]],"date-time":"2013-03-18T02:15:03Z","timestamp":1363572903000},"page":"559-570","source":"Crossref","is-referenced-by-count":134,"title":["Itraconazole in chronic cavitary pulmonary aspergillosis: a randomised controlled trial and systematic review of literature"],"prefix":"10.1111","volume":"56","author":[{"given":"Ritesh","family":"Agarwal","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gella","family":"Vishwanath","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashutosh N.","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandeep","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis and Imaging Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dheeraj","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arunaloke","family":"Chakrabarti","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2001.tb00006.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/376526"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2008.06.049"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2009.02.008"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2009.01.019"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.11.089441"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.112.2.541"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-3879(70)90015-2"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1086\/525258"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2005.08.022"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-2441"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(90)70263-H"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.1988.tb03653.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.46.11.839"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.1994.tb00296.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-90-481-2408-4_35"},{"key":"e_1_2_9_18_1","first-page":"557","article-title":"Multicenter clinical trial of itraconazole in the treatment of pulmonary aspergilloma. 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