{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:47:32Z","timestamp":1791557252992,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,5,14]],"date-time":"2013-05-14T00:00:00Z","timestamp":1368489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Azole resistance in <jats:italic><jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>spergillus<\/jats:italic> is emerging in <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>uropean and <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>sian countries. As azoles are mainstay of therapy in the management of aspergillosis, azole resistance has serious implications in patient management. We report the emergence of resistance to triazoles in environmental <jats:italic><jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>spergillus fumigatus<\/jats:italic> isolates in <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>ran. The TR<jats:sub>34<\/jats:sub>\/L98H mutation was the only resistance mechanism. Overall 3.3% of the <jats:italic><jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>. fumigatus<\/jats:italic> isolates from hospital surroundings in <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ari and <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>ehran had the same TR<jats:sub>34<\/jats:sub>\/L98H STR<jats:italic>Af<\/jats:italic> genotype and were related to some resistant clinical and environmental TR<jats:sub>34<\/jats:sub>\/L98H isolates from the <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>etherlands and <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>ndia. It is emphasised that routine resistance surveillance studies focusing on environmental and clinical samples are warranted to yield the true prevalence of azole resistance in <jats:italic><jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>. fumigatus<\/jats:italic> in <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>ran.<\/jats:p>","DOI":"10.1111\/myc.12089","type":"journal-article","created":{"date-parts":[[2013,5,14]],"date-time":"2013-05-14T09:02:59Z","timestamp":1368522179000},"page":"659-663","source":"Crossref","is-referenced-by-count":104,"title":["Environmental study of azole\u2010resistant <i><scp>A<\/scp>spergillus fumigatus<\/i> with TR<sub>34<\/sub>\/L98H mutations in the <i>cyp51<\/i>A gene in <scp>I<\/scp>ran"],"prefix":"10.1111","volume":"56","author":[{"given":"Hamid","family":"Badali","sequence":"first","affiliation":[{"name":"Department of Medical Mycology and Parasitology\/Invasive Fungi Research Center (IFRC) School of Medicine Mazandaran University of Medical Sciences Sari Iran"},{"name":"Molecular and Cell Biology Research Centre (MCBRC) School of Medicine Mazandaran University of Medical Sciences Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afsane","family":"Vaezi","sequence":"additional","affiliation":[{"name":"Department of Medical Mycology and Parasitology\/Invasive Fungi Research Center (IFRC) School of Medicine Mazandaran University of Medical Sciences Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iman","family":"Haghani","sequence":"additional","affiliation":[{"name":"Department of Medical Mycology and Parasitology\/Invasive Fungi Research Center (IFRC) School of Medicine Mazandaran University of Medical Sciences Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed A.","family":"Yazdanparast","sequence":"additional","affiliation":[{"name":"Department of Medical Parasitology and Mycology School of Allied Medicine 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