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The production of proteinases is encoded by a family of 10 genes known as<jats:styled-content style=\"fixed-case\">SAP<\/jats:styled-content>, which are distributed differently among the species. The expression of these genes may be influenced by environmental conditions, which generally result in a higher fungal invasive potential. Non\u2010pathogenic<jats:italic><jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>andida<\/jats:italic>spp. usually have fewer<jats:styled-content style=\"fixed-case\">SAP<\/jats:styled-content>genes, which are not necessarily expressed in the genome. Exposure to subinhibitory concentrations of antifungal agents promotes the development of resistant strains with an increased expression of<jats:styled-content style=\"fixed-case\">SAP<\/jats:styled-content>genes. In general,<jats:italic><jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>andida<\/jats:italic>spp. isolates that are resistant to antifungals show a higher secretion of Sap than the susceptible isolates. The relationship between Sap secretion and the susceptibility profile of the isolates is of great interest, although the role of<jats:styled-content style=\"fixed-case\">SAP<\/jats:styled-content>s in the development of resistance to antifungal agents remains still unclear. This review is the first one to address these issues.<\/jats:p>","DOI":"10.1111\/myc.12095","type":"journal-article","created":{"date-parts":[[2013,6,5]],"date-time":"2013-06-05T01:37:06Z","timestamp":1370396226000},"page":"1-11","source":"Crossref","is-referenced-by-count":62,"title":["Aspartic proteinases of<i><scp>C<\/scp>andida<\/i>spp.: role in pathogenicity and antifungal resistance"],"prefix":"10.1111","volume":"57","author":[{"given":"Naiara C.","family":"Silva","sequence":"first","affiliation":[{"name":"Microbiology and Immunology Department Federal University of Alfenas (UNIFAL\u2010MG) Alfenas Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9ssica M.","family":"Nery","sequence":"additional","affiliation":[{"name":"Microbiology and Immunology Department Federal University of Alfenas (UNIFAL\u2010MG) Alfenas Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda L. 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