{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:13:15Z","timestamp":1792181595613,"version":"4.4.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,6,12]],"date-time":"2013-06-12T00:00:00Z","timestamp":1370995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2014,1]]},"abstract":"Summary<\/jats:title>\n \n Pulmonary mucormycosis (PM) is a life\u2010threatening opportunistic mycosis with a variable clinical evolution and few prognostic markers for outcome assessment. Several clinical risk factors for poor outcome present at the diagnosis of PM were analyzed in 75 consecutive hematology patients from 2000\u20132012. Significant variables (\n P<\/jats:italic>\n \u00a0<\u00a00.1) were entered into a multivariate Cox\u2010proportional hazard regression model adjusting for baseline APACHE II to identify independent risk factors for mortality within 28 days. Twenty\u2010eight of 75 patients died within 4\u2010week follow up. A lymphocyte count <\u00a0100\/mm\n 3<\/jats:sup>\n at the time of diagnosis (adjusted hazard ratio 4.0, 1.7\u20139.4,\n P<\/jats:italic>\n \u00a0=\u00a00.01) and high level of lactate dehydrogenase (AHR 3.7, 1.3\u201310.2,\n P<\/jats:italic>\n \u00a0=\u00a00.015) were independent predictors along with APACHE II score for 28\u2010day mortality. A weighted risk score based on these 3 baseline variables accurately identified non\u2010surviving patients at 28 days (area under the receiver\u2010operator curve of 0.87, 0.77\u20130.93,\n P<\/jats:italic>\n \u00a0<\u00a00.001). A risk score >\u00a022 was associated with 8\u2010fold high rates of mortality (\n P<\/jats:italic>\n \u00a0<\u00a00.0001) within 28 days of diagnosis and median survival of 7 days versus\n \n 28 days in patients with risk scores\n \n 22. We found that APACHE II score, severe lymphocytopenia and high LDH levels at the time of PM diagnosis were independent markers for rapid disease progression and death.\n <\/jats:p>","DOI":"10.1111\/myc.12101","type":"journal-article","created":{"date-parts":[[2013,6,12]],"date-time":"2013-06-12T05:04:46Z","timestamp":1371013486000},"page":"49-55","source":"Crossref","is-referenced-by-count":33,"title":["Risk factors for early mortality in haematological malignancy patients with pulmonary mucormycosis"],"prefix":"10.1111","volume":"57","author":[{"given":"Russell E.","family":"Lewis","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Infection Control and Employee Health The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah P.","family":"Georgiadou","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Infection Control and Employee Health The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fotis","family":"Sampsonas","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Infection Control and Employee Health The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Chamilos","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Infection Control and Employee Health The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios P.","family":"Kontoyiannis","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Infection Control and Employee Health The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2006.06.003"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir866"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.18.3.556-569.2005"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-03-316430"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2011.10.009"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/500212"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/590004"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/13693786.2012.669502"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1086\/588660"},{"key":"e_1_2_7_11_1","volume-title":"Medically Important Fungi","author":"Larone 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in hematologic patients","volume":"89","author":"Pagano L","year":"2004","journal-title":"Haematologica"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.3983214.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis308"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-07-366526"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir885"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1086\/599105"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fmyc.12101","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.12101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T11:35:51Z","timestamp":1696246551000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.12101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,12]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1111\/myc.12101"],"URL":"https:\/\/doi.org\/10.1111\/myc.12101","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718113665.793484126","asserted-by":"object"}]},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,12]]}}}